期刊
PATHOGENS AND DISEASE
卷 74, 期 8, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/femspd/ftw099
关键词
bacterial pathogen; Listeria; Burkholderia; Rickettsia; cytoskeleton; actin-based motility
资金
- National Institutes of Health [R01 AI109044, R21 AI109270, R21 AI119743]
- American Heart Association [14PRE18150013]
A diverse spectrum of intracellular bacterial pathogens that inhabit the cytosol have evolved the ability to polymerize actin on their surface to power intracellular actin-based motility (ABM). These include species of Listeria, Burkholderia and Rickettsia, as well as Shigella and Mycobacteria. Here, we provide an overview of the roles of bacterial ABM in survival and virulence. Moreover, we survey the molecular mechanisms of actin polymerization in host cells and describe how bacterial pathogens mimic or harness the full diversity of these mechanisms for ABM. Finally, we present ABM through a new lens by comparing motility mechanisms between related species of Listeria, Burkholderia and Rickettsia. Through these comparisons, we hope to illuminate how exploitation of different actin polymerization mechanisms influences ABM as well as pathogenicity and virulence in humans and other animals.
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