期刊
PARKINSONS DISEASE
卷 2016, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2016/9060649
关键词
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资金
- Camelia Botnar Foundation
- Parkinson Schweiz
- Jacques and Gloria Gossweiler Foundation
- Freiwillige Akademische Gesellschaft Basel
- Gottfried und Julia Bangerter-Rhyner Foundation
- Swiss National Science Foundation
- Hedwig Widmer Foundation
- UCB Pharma AG
- Abbvie AG
- General Electrics
- Swiss Multiple Sclerosis Society
- Roche AG
Cognitive decline is common with the progression of Parkinson's disease (PD). Different candidate biomarkers are currently studied for the risk of dementia in PD. Several studies have shown that quantitative EEG (QEEG) is a promising predictor of PD-related cognitive decline. In this paper we briefly outline the basics of QEEG analysis and analyze the recent publications addressing the predictive value of QEEG in the context of cognitive decline in PD. The MEDLINE database was searched for relevant publications from January 01, 2005, to March 02, 2015. Twenty-four studies reported QEEG findings in various cognitive states in PD. Spectral and connectivity markers of QEEG could help to discriminate between PD patients with different level of cognitive decline. QEEG variables correlate with tools for cognitive assessment over time and are associated with significant hazard ratios to predict PD-related dementia. QEEG analysis shows high test-retest reliability and avoids learning effects associated with some neuropsychological testing; it is noninvasive and relatively easy to repeat.
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