4.1 Review

Current Research Therapeutic Strategies for Alzheimer's Disease Treatment

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Immunotherapeutic Approaches for Alzheimer's Disease

Thomas Wisniewski et al.

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Drug development for tauopathies

F. Grueninger

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Post-mortem analysis of neuroinflammatory changes in human Alzheimer's disease

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Brain metabolic stress and neuroinflammation at the basis of cognitive impairment in Alzheimer's disease

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Masitinib for the treatment of mild to moderate Alzheimer's disease

Jaume Folch et al.

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Nerve Growth Factor Gene Therapy Activation of Neuronal Responses in Alzheimer Disease

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Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau

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Drug Access to the Central Nervous System in Alzheimer's Disease: Preclinical and Clinical Insights

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Tau Aggregation Inhibitor Therapy: An Exploratory Phase 2 Study in Mild or Moderate Alzheimer's Disease

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Complex Disposition of Methylthioninium Redox Forms Determines Efficacy in Tau Aggregation Inhibitor Therapy for Alzheimer's Disease

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Amyloid-directed monoclonal antibodies for the treatment of Alzheimer's disease: the point of no return?

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Investigational drugs in Alzheimer's disease: current progress

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Microtubule-associated protein tau as a therapeutic target in Alzheimer's disease

Khalid Iqbal et al.

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Amyloid-based immunotherapy for Alzheimer's disease in the time of prevention trials: the way forward

Francesco Panza et al.

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Targeting the β secretase BACE1 for Alzheimer's disease therapy

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LANCET NEUROLOGY (2014)

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Dietary and lifestyle guidelines for the prevention of Alzheimer's disease

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Nutrition and the brain: what advice should we give?

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Neuroprotective effects of the amylin analogue pramlintide on Alzheimer's disease pathogenesis and cognition

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Clinical trial of an inhibitor of RAGE-Aβ interactions in Alzheimer disease

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The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer's Disease

Tara L. Spires-Jones et al.

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Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

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Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

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Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity

Kent E. S. Matlack et al.

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Review Clinical Neurology

Fyn kinase inhibition as a novel therapy for Alzheimer's disease

Haakon B. Nygaard et al.

ALZHEIMERS RESEARCH & THERAPY (2014)

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β-secretase inhibitor; a promising novel therapeutic drug in Alzheimer's disease

Kelly Willemijn Menting et al.

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Amylin and its analogs: a friend or foe for the treatment of Alzheimer's disease?

Wei Qiao Qiu et al.

FRONTIERS IN AGING NEUROSCIENCE (2014)

Article Biotechnology & Applied Microbiology

Alzheimer disease immunotherapeutics Then and now

Harashish Jindal et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2014)

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Physiological and pathological phosphorylation of tau by Cdk5

Taeko Kimura et al.

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Rational heterodoxy: Cholesterol reformation of the amyloid doctrine

Michael A. Castello et al.

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Pharmacokinetics and Pharmacodynamics of CHF5074 After Short-term Administration in Healthy Subjects

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Importance of the nicotinic acetylcholine receptor system in the prefrontal cortex

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Bapineuzumab and solanezumab for Alzheimer's disease: is the 'amyloid cascade hypothesis' still alive?

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Connecting Type 2 diabetes to Alzheimer's disease

Fernanda G. De Felice

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Alzheimer's disease and insulin resistance: translating basic science into clinical applications

Fernanda G. De Felice

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A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease

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Review Chemistry, Medicinal

Profile of gantenerumab and its potential in the treatment of Alzheimer's disease

Dijana Novakovic et al.

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Review Geriatrics & Gerontology

Importance and management of micronutrient deficiencies in patients with Alzheimer's disease

Brbara Rita Cardoso et al.

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Article Clinical Neurology

Are tau aggregates toxic or protective in tauopathies?

Catherine M. Cowan et al.

FRONTIERS IN NEUROLOGY (2013)

Review Medicine, Research & Experimental

Deregulated Cdk5 Activity Is Involved in Inducing Alzheimer's Disease

Varsha Shukla et al.

ARCHIVES OF MEDICAL RESEARCH (2012)

Review Biochemistry & Molecular Biology

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Yadong Huang et al.

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Effects of Single Doses of Avagacestat (BMS-708163) on Cerebrospinal Fluid Aβ Levels in Healthy Young Men

Gary Tong et al.

CLINICAL DRUG INVESTIGATION (2012)

Review Chemistry, Medicinal

Is RAGE still a therapeutic target for Alzheimer's disease?

Richard J. Deane

FUTURE MEDICINAL CHEMISTRY (2012)

Article Neurosciences

JNK3 Perpetuates Metabolic Stress Induced by Aβ Peptides

Sung Ok Yoon et al.

NEURON (2012)

Article Pharmacology & Pharmacy

GSK3 beta inhibition is involved in the neuroprotective effects of cyclin-dependent kinase inhibitors in neurons

Aurelio Vazquez de la Torre et al.

PHARMACOLOGICAL RESEARCH (2012)

Article Medicine, Research & Experimental

Neurotoxicity of Amyloid β-Protein: Synaptic and Network Dysfunction

Lennart Mucke et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)

Article Medicine, Research & Experimental

Trafficking and Proteolytic Processing of APP

Christian Haass et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)

Review Medicine, General & Internal

Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease

Darin Jaturapatporn et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2012)

Article Chemistry, Medicinal

γ-Secretase Inhibitors and Modulators for the Treatment of Alzheimer's Disease: Disappointments and Hopes

Bruno P. Imbimbo et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2011)

Review Neurosciences

Fyn, a Potential Target for Alzheimer's Disease

Kai Yang et al.

JOURNAL OF ALZHEIMERS DISEASE (2011)

Article Geriatrics & Gerontology

Efficacy of PPAR-γ agonist pioglitazone in mild Alzheimer disease

Tomohiko Sato et al.

NEUROBIOLOGY OF AGING (2011)

Review Biotechnology & Applied Microbiology

Identifying and validating biomarkers for Alzheimer's disease

Christian Humpel

TRENDS IN BIOTECHNOLOGY (2011)

Review Clinical Neurology

The beta-secretase enzyme BACE1 as a therapeutic target for Alzheimer's disease

Robert Vassar et al.

ALZHEIMERS RESEARCH & THERAPY (2011)

Review Neurosciences

Can Nutrients Prevent or Delay Onset of Alzheimer's Disease?

Patrick J. G. H. Kamphuis et al.

JOURNAL OF ALZHEIMERS DISEASE (2010)

Article Immunology

Measurement of anti-beta amyloid antibodies in human blood

Paul Szabo et al.

JOURNAL OF NEUROIMMUNOLOGY (2010)

Article Multidisciplinary Sciences

Effects of Long-Term Pioglitazone Treatment on Peripheral and Central Markers of Aging

Eric M. Blalock et al.

PLOS ONE (2010)

Article Multidisciplinary Sciences

Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models

Janet van Eersel et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Clinical Neurology

PGC-1α Expression Decreases in the Alzheimer Disease Brain as a Function of Dementia

Weiping Qin et al.

ARCHIVES OF NEUROLOGY (2009)

Article Geriatrics & Gerontology

18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease

Norman R. Relkin et al.

NEUROBIOLOGY OF AGING (2009)

Article Geriatrics & Gerontology

A randomized controlled study on effects of ibuprofen on cognitive progression of Alzheimer's disease

Patrizio Pasqualetti et al.

AGING CLINICAL AND EXPERIMENTAL RESEARCH (2009)

Review Clinical Neurology

Amyloid-degrading enzymes as therapeutic targets in Alzheimer's disease

Natalia N. Nalivaeva et al.

CURRENT ALZHEIMER RESEARCH (2008)

Review Pharmacology & Pharmacy

The role of the cell surface LRP and soluble LRP in blood-brain barrier a clearance in Alzheimer's Disease

R. Deane et al.

CURRENT PHARMACEUTICAL DESIGN (2008)

Article Multidisciplinary Sciences

Liposomal vaccines with conformation-specific amyloid peptide antigens define immune response and efficacy in APP transgenic mice

Andreas Muhs et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Pharmacology & Pharmacy

The role of CDK5/P25 formation/inhibition in neurodegeneration

Antoni Camins et al.

DRUG NEWS & PERSPECTIVES (2006)

Article Biochemistry & Molecular Biology

Understanding molecular mechanisms of proteolysis in Alzheimer's disease: Progress toward therapeutic interventions

M Higuchi et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2005)

Review Pharmacology & Pharmacy

Targeting JNK3 for the treatment of neurodegenerative disorders

L Resnick et al.

DRUG DISCOVERY TODAY (2004)

Article Medicine, Research & Experimental

NSAIDs and enantiomers of flurbiprofen target γ-secretase and lower Aβ42 in vivo

JL Eriksen et al.

JOURNAL OF CLINICAL INVESTIGATION (2003)