期刊
NEURAL PLASTICITY
卷 2016, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2016/3425908
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资金
- Swiss National Science Foundation [31003A_155898]
- National Center for Competence in Research (NCCR) SYNAPSY
- Synapsis Foundation for Alzheimer Research
- Beatrice Ederer-Weber Stiftung
- Alzheimer's Association New Investigator Research Grant
- Swiss National Science Foundation (SNF) [31003A_155898] Funding Source: Swiss National Science Foundation (SNF)
Our memories are the records of the experiences we gain in our everyday life. Over time, they slowly transform from an initially unstable state into a long-lasting form. Many studies have been investigating from different aspects how a memory could persist for sometimes up to decades. In this review, we highlight three of the greatly addressed mechanisms that play a central role for a given memory to endure: the allocation of the memory to a given neuronal population and what brain areas are recruited for its storage; the structural changes that underlie memory persistence; and finally the epigenetic control of gene expression that might regulate and support memory perseverance. Examining such key properties of a memory is essential towards a finer understanding of its capacity to last.
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