期刊
CLINICAL MEDICINE INSIGHTS-ONCOLOGY
卷 16, 期 -, 页码 -出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/11795549221105027
关键词
Volatile organic compounds; digestive cancer; gas biopsy; diagnosis; meta-analysis
类别
Volatile organic compounds have the potential to diagnose gastrointestinal cancer with relatively high sensitivity, specificity, and AUC.
BACKGROUND: Volatile organic compounds (VOCs) have been involved in cancer diagnosis via breath, urine. and feces. We aimed to assess the diagnostic ability of VOCs on digestive cancers. METHODS: We systematically reviewed prospective clinical trials evaluating VOCs' diagnostic ability on esophageal, gastric, colorectal. hepatic, and pancreatic cancer (PC). Databases including PubMed and Ovid-Medline were searched. RESULTS: A total of 35 trials with 5314 patient-times qualified for inclusion. The pooled sensitivity of VOCs diagnosing gastroesophageal cancer from healthy controls is 0.89 (95% confidence interval [CI]: 0.82-0.94), the pooled specificity is 0.890 (95% CI: 0.84-0.93). and area under the curve (AUC) of the summary receiver operating characteristic curve is 0.95 (95% CI: 0.93-0.95). The pooled sensitivity of VOCs diagnosing colorectal cancer from heathy controls is 0.92 (95% CI: 0.85-0.96). the pooled specificity is 0.88 (95% CI: 0.77-0.94), and the AUC is 0.96 (95% CI: 0.94-0.97). The pooled sensitivity of VOCs distinguishing gastrointestinal (GI) cancer from precancerous lesions is 0.84 (95% CI: 0.67-0.92), the pooled specificity is 0.74 (95% CI: 0.43-0.91). and the AUC is 0.87 (95% CI: 0.84-0.89). The pooled sensitivity of VOCs diagnosing hepatocellular carcinoma is 0.68 (95% CI: 0.52-0.81). the pooled specificity is 0.81 (95% CI: 0.47-0.96). and the AUC is 0.78 (95% CI: 0.74-0.81). The pooled sensitivity of VOCs diagnosing PC is 0.88 (95% CI: 0.80-0.93), the pooled specificity is 0.82 (95% CI: 0.62-0.93). and the AUC is 0.92 (95% CI: 0.89-0.94). CONCLUSIONS: Volatile organic compounds have potential role in diagnosing GI cancer with comparatively high sensitivity, specificity, and AUC.
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