New Method for the Preparation of 2,3-Disubstituted 2,3-Dihydrothiazolo[3,2-a]pyrimidines

A new approach to the synthesis of 2,3-disubstituted 2,3-dihydrothiazolo[3,2-a]pyrimidines under microwave activation conditions has been developed. The method consists in the nucleophilic addition of methanol to 2-arylmethylidene derivatives of thiazolo[3,2-a]pyrimidine followed by intramolecular rearrangement to form 3,5-diaryl-2,3-dihydrothiazolo[3,2-a]pyrimidine-2,6-dicarboxylates.

Automated summary

A new method for the synthesis of 2,3-disubstituted 2,3-dihydrothiazolo[3,2-a]pyrimidines has been developed using microwave activation conditions and nucleophilic addition of methanol.