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Article
Immunology
Tara C. Bouton et al.
Summary: The majority of Delta- and Omicron-infected cohort culture-converted by day 6, with no further impact of booster vaccination on sterilization or cycle threshold decay. Rapid antigen testing may provide reassurance of lack of infectiousness, though guidance to mask for days 6-10 is supported by our finding that 17% of participants remained culture-positive after isolation.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Medicine, General & Internal
Rosanna W. Peeling et al.
Summary: Diagnostics play a crucial role in the response to the COVID-19 pandemic. Molecular tests like PCR are recommended for confirming diagnosis in symptomatic individuals, while antigen rapid detection tests have the advantage of being easier to perform with faster results and lower cost. Antibody tests can inform public policy but should not be used as proof of immunity. All three types of tests continue to be important in transitioning from pandemic response to control.
Article
Medicine, General & Internal
Victoria Hall et al.
Summary: This study investigated the duration and effectiveness of immunity among healthcare workers in the United Kingdom. It found that two doses of the BNT162b2 vaccine provided high short-term protection against SARS-CoV-2 infection, but this protection significantly decreased after six months. However, infection-acquired immunity boosted by vaccination remained high, even more than one year after infection.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Anastasia S. Lambrou et al.
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2022)
Article
Multidisciplinary Sciences
Frauke Muecksch et al.
Summary: Receiving three doses of an mRNA vaccine can provide protection against the Omicron variant and induce the production of more potent and broader antibodies. This is due to the expansion and evolution of memory B cell clones, particularly the newly emerging clones that target more conserved regions.
Article
Public, Environmental & Occupational Health
Brian Lefferts et al.
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2022)
Article
Multidisciplinary Sciences
Laura C. Rosella et al.
Summary: This study reports the establishment of a workplace frequent rapid antigen test (RAT) program in Canada, which effectively mitigated COVID-19 transmission in workplaces and received high ratings from employers.
Article
Medicine, General & Internal
Apurv Soni et al.
Summary: This study compares the performance of Ag-RDTs in detecting the Delta and Omicron variants of SARS-CoV-2. The results show that there is no significant difference in sensitivity between the two variants, and there is also no significant difference in sensitivity of Ag-RDTs for positive results that last for 48 hours. Serial testing can improve the sensitivity of Ag-RDTs.
ANNALS OF INTERNAL MEDICINE
(2022)
Article
Immunology
Andrew Pekosz et al.
Summary: Recent studies indicate that SARS-CoV-2 antigen testing demonstrates a higher positive predictive value in the early stages of infection and shows good consistency with culture results. This testing method can significantly aid in determining the risk of carrying infectious virus.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
John G. Routsias et al.
Summary: PCR is widely used for diagnosing SARS-CoV-2 infection due to its high sensitivity, but rapid antigen tests (RATs) may outperform PCR in identifying infectious individuals. Variability in limit of detection was observed among different RATs, with the most effective ones achieving sensitivities up to 99.1% for detecting contagious patients.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Andrew Pekosz et al.
Summary: SARS-CoV-2 antigen testing may be positive early in the disease course, aiding in determining infectious risk, with a slightly better detection of infectious virus compared to rt-PCR.
CLINICAL INFECTIOUS DISEASES
(2021)
