期刊
MULTIPLE SCLEROSIS JOURNAL
卷 23, 期 7, 页码 1000-1007出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1352458516667566
关键词
First demyelinating event; first clinical diagnosis; stress; stressful life events; multiple sclerosis; risk factors
资金
- Australian Research Council [100100511]
- National Health and Medical Research Council of Australia
- Multiple Sclerosis Research Australia
- Royal Australasian College of Physicians
- MS Research Australia
- US National Multiple Sclerosis Society
- Poola Foundation
- Health Research Council of New Zealand
- MS Society of Tasmania
- Bayer Schering Pharma
- Biogen Idec, Inc.
- Australian National Health and Medical Research Council Career Development Fellowships
- Australian Research Council Future Fellowship
Background: There is substantial evidence that stress increases multiple sclerosis disease activity, but limited evidence on its association with the onset of multiple sclerosis. Objective: To examine the association between stressful life events and risk of first demyelinating event (FDE). Methods: This was a multicentre incident case-control study. Cases (n=282 with first diagnosis of central nervous system (CNS) demyelination, including n=216 with classic FDE') were aged 18-59years. Controls without CNS demyelination (n=558) were matched to cases on age, sex and study region. Stressful life events were assessed using a questionnaire based on the Social Readjustment Rating Scale. Results: Those who suffered from a serious illness in the previous 12months were more likely to have an FDE (odds ratio (OR)=2.35 (1.36, 4.06), p=0.002), and when we limited our reference group to those who had no stressful life events, the magnitude of effect became stronger (OR=5.41 (1.80, 16.28)). The total stress number and stress load were not convincingly associated with the risk of an FDE. Conclusion: Cases were more likely to report a serious illness in the previous 12months, which could suggest that a non-specific illness provides an additional strain to an already predisposed immune system.
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