期刊
MICROMACHINES
卷 7, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/mi7060094
关键词
extreme point-of-care testing; low-resource settings; emergencies; disasters; infectious disease diagnostics; centripetal (centrifugal) microfluidics; polymerase chain reaction; isothermal amplification; GenePOC
类别
资金
- Fonds de partenariat pour un Quebec innovant et en sante (Ministere de l'Economie, de l'Innovation et des Exportations, Gouvernement du Quebec, Canada)
Extreme point-of-care (POC) testing for infections, as performed (endured) in low-resource settings, developing countries, tropical areas, or in conditions following emergency crises or natural disasters, must be undertaken under environmental, logistic, and societal conditions which impose a significant deal of stress on local human populations and healthcare providers. For disease diagnostics or management, simple and robust biomedical equipment and reagents are required and needed. This chapter aims to overview some of these stresses (requirements) and intends to describe some of the solutions already engineered at the heart of centripetal (centrifugal) microfluidic platforms such as that of GenePOC Inc. to enable rapid, robust, and reproducible nucleic acid-based diagnostics of infectious diseases, to better control the morbidity and mortality of infections and the expanding threat posed by antimicrobial resistance.
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