期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 70, 期 12, 页码 885-891出版社
PHARMACEUTICAL SOC JAPAN
关键词
B cell-specific Moloney murine leukemia virus insertion region 1 (BMI1) promoter inhibitory activity; Mammea siamensis; Andrographis paniculata; coumarin; labdane diterpene
资金
- KAKENHI [20H03394, 20K16024]
- Japan Society for the Promotion of Science and JST SPRING [JPMJSP2109]
A new coumarin derivative and 30 known compounds were isolated from Mammea siamensis and Andrographis paniculata. These compounds exhibited BMI1 promoter inhibitory activity, and one compound showed high cytotoxicity against DU145 cells.
A new coumarin derivative (1) and 30 known compounds were isolated from Mammea siamensis and Andrographis paniculata, guided by B cell-specific Moloney murine leukemia virus insertion region 1 (BMI1) promoter inhibitory activity. Among the isolated compounds, 15 compounds showed BMI1 promoter inhibi-tory activity, and five compounds were found to be cytotoxic. 14-Deoxy-11,12-dehydroandrographolide (18) was highly cytotoxic to DU145 cells with an IC50 value of 25.4 mu M. Western blotting analysis of compound 18 in DU145 cells suggested that compound 18 suppresses BMI1 expression.
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