Myocardial regeneration protocols towards the routine clinical scenario: An unseemly path from bench to bedside

Heart failure secondary to cardiomyocyte loss and/or dysfunction is the number one killer worldwide. The field of myocardial regeneration with its far-reaching primary goal of cardiac remuscularization and its hard-to-accomplish translation from bench to bedside, has been filled with ups and downs, steps forward and steps backward, controver-sies galore and, unfortunately, scientific scandals. Despite the present morass in which cardiac remuscularization is stuck in, the search for clinically effective regenerative approaches remains keenly active. Starting with a concise overview of the still highly debated regenerative capacity of the adult mammalian heart, we focus on the main inter-ventions, that have reached or are close to clinical use, critically discussing key findings, successes, and failures. Finally, some promising and innovative approaches for myocardial repair/regeneration still at the pre-clinical stage are discussed to offer a holistic view on the future of myocardial repair/regeneration for the prevention/management of heart failure in the clinical scenario.

Automated summary

Heart failure is the number one killer worldwide. The field of cardiac remuscularization faces challenges, but the search for clinically effective regenerative approaches remains active. This article provides an overview of the regenerative capacity of the adult mammalian heart and discusses interventions that have reached or are close to clinical use, as well as promising and innovative approaches for myocardial repair/regeneration.