Prognostic influence for hilar cholangiocarcinoma and comparisons of prognostic values of Mayo staging and TNM staging systems

Article Oncology

Adjuvant chemotherapy for perihilar cholangiocarcinoma: A population-based comparative cohort study

Sivesh K. Kamarajah et al.

Summary: This study found that adjuvant chemotherapy following resection for perihilar cholangiocarcinoma (hCCA) was associated with improved survival, even in margin-negative and node-negative disease.

EJSO (2022)

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Article Gastroenterology & Hepatology

Cholangiocarcinoma landscape in Europe: Diagnostic, prognostic and therapeutic insights from the ENSCCA Registry

Laura Izquierdo-Sanchez et al.

Summary: This study investigates the clinical course of cholangiocarcinoma in a pan-European cohort and finds that the disease is frequently diagnosed at an advanced stage and a proportion of patients fail to receive cancer-specific therapies, resulting in a poor prognosis.

JOURNAL OF HEPATOLOGY (2022)

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Article Oncology

Adjuvant radiotherapy improves long-term survival after resection for gallbladder cancer A population-based cohort study

Sivesh K. Kamarajah et al.

Summary: This study found that adjuvant radiotherapy following resection is associated with improved survival in gallbladder cancer patients, even in cases with negative lymph nodes and margins. These findings suggest the addition of radiotherapy to multimodality therapy for gallbladder cancer.

EJSO (2022)

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Article Surgery

Textbook outcome after major hepatectomy for perihilar cholangiocarcinoma - definitions and influencing factors

Christian Benzing et al.

Summary: This study proposed a uniform definition of textbook outcome for patients undergoing major hepatectomy for perihilar cholangiocarcinoma through a systematic literature review. It identified preoperative biliary drainage and left-sided resection as factors influencing textbook outcome.

LANGENBECKS ARCHIVES OF SURGERY (2022)

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Article Surgery

Prognostic Impact of Paraaortic Lymph Node Metastasis in Extrahepatic Cholangiocarcinoma

Nobuhito Nitta et al.

Summary: This study suggests that the overall survival of resected EHCC patients with PALNM is significantly better than unresected patients, and comparable to patients with regional lymph node metastasis. Several independent prognostic factors were identified through multivariate analysis.

WORLD JOURNAL OF SURGERY (2021)

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Review Oncology

Biliary Strictures and Cholangiocarcinoma - Untangling a Diagnostic Conundrum

Alexander Ney et al.

Summary: Cholangiocarcinoma is a rare and highly aggressive biliary tract malignancy that is difficult to diagnose early. Standard serum markers lack sensitivity and specificity, driving the search for novel biomarkers for screening and early detection. However, clinical translation of these biomarkers is slow and further validation in larger patient cohorts is needed.

FRONTIERS IN ONCOLOGY (2021)

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Article Medicine, General & Internal

Prognostic Impact of Perioperative CA19-9 Levels in Patients with Resected Perihilar Cholangiocarcinoma

Jong Woo Lee et al.

Summary: This study aimed to investigate the predictive value of changes in CA19-9 levels for patients undergoing curative resection for perihilar cholangiocarcinoma. It was found that patients in the non-normalization group had significantly worse overall survival, and a high postoperative CA19-9 level was identified as an independent prognostic factor in resected perihilar cholangiocarcinoma patients.

JOURNAL OF CLINICAL MEDICINE (2021)

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Review Pathology

Targeting Lymphangiogenesis and Lymph Node Metastasis in Liver Cancer

Sukanya Roy et al.

Summary: Increased lymphangiogenesis and lymph node metastasis are important prognostic indicators in aggressive hepatobiliary malignancies. This review provides a detailed perspective on alterations in the hepatic lymphatic system during liver malignancies, as well as potential molecular signaling mechanisms and growth factors for future therapeutic targets. Targeting tumor-associated lymphangiogenesis presents current challenges and opportunities for effective therapeutic interventions.

AMERICAN JOURNAL OF PATHOLOGY (2021)

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Review Oncology

Approach to Resectable Biliary Cancers

Kimberly Washington et al.

Summary: Biliary malignancies, including intrahepatic cholangiocarcinomas, hilar cholangiocarcinomas, and gallbladder carcinomas, require different surgical management strategies based on tumor location and characteristics. Neoadjuvant chemotherapy is not routinely used before surgery for biliary malignancies.

CURRENT TREATMENT OPTIONS IN ONCOLOGY (2021)

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Review Oncology

Current Surgical Management of Peri-Hilar and Intra-Hepatic Cholangiocarcinoma

Andrea Lauterio et al.

Summary: The treatment of peri-hilar and intrahepatic cholangiocarcinoma continues to evolve with different strategies and surgical approaches, including advancements in radiological and chemotherapeutic techniques. Surgical resection remains the main curative option for intrahepatic cholangiocarcinoma, with liver transplantation now being considered as a potential treatment for CCA patients thanks to recent improvements in outcomes and survival rates.

CANCERS (2021)

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Article Oncology

Outcomes of vascular resection associated with curative intent hepatectomy for intrahepatic cholangiocarcinoma

Simone Conci et al.

EJSO (2020)

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Review Gastroenterology & Hepatology

Liver Transplantation for Peri-hilar Cholangiocarcinoma

Ek Khoon Tan et al.

JOURNAL OF GASTROINTESTINAL SURGERY (2020)

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Review Gastroenterology & Hepatology

Surgery for cholangiocarcinoma

Umberto Cillo et al.

LIVER INTERNATIONAL (2019)

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Article Surgery

Cholangiocarcinoma

Adeel S. Khan et al.

SURGICAL CLINICS OF NORTH AMERICA (2019)

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Article Oncology

Gemcitabine, Cisplatin, and nab-Paclitaxel for the Treatment of Advanced Biliary Tract Cancers: A Phase 2 Clinical Trial

Rachna T. Shroff et al.

JAMA ONCOLOGY (2019)

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Review Gastroenterology & Hepatology

Pathogenesis, diagnosis and treatment of premalignant and malignant stages of cholangiocarcinoma in primary sclerosing cholangitis

Marit M. Grimsrud et al.

LIVER INTERNATIONAL (2019)

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Article Oncology

Coming of a precision era of the staging systems for intrahepatic cholangiocarcinoma?

Zhangjun Cheng et al.

CANCER LETTERS (2019)

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Review Oncology

Biliary tract cancer: current challenges and future prospects

Michele Ghidini et al.

CANCER MANAGEMENT AND RESEARCH (2019)

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Article Surgery

CA19-9 in intrahepatic cholangiocarcinoma. A diagnostic and prognostic armamentarium?

B. Juntermanns et al.

CHIRURG (2018)

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Article Oncology

Evaluation of the 8th edition American Joint Commission on Cancer (AJCC) staging system for patients with intrahepatic cholangiocarcinoma: A surveillance, epidemiology, and end results (SEER) analysis

Yuhree Kim et al.

JOURNAL OF SURGICAL ONCOLOGY (2017)

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Article Gastroenterology & Hepatology

Prognostic value of lymphovascular invasion in BismuthCorlette type IV hilar cholangiocarcinoma

Bei Li et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2017)

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Review Gastroenterology & Hepatology

Multimodality imaging of intrahepatic cholangiocarcinoma

Kelly Fabrega-Foster et al.

HEPATOBILIARY SURGERY AND NUTRITION (2017)

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Article Surgery

Prognostic impact of lymph node metastasis in distal cholangiocarcinoma

M. Kiriyama et al.

BRITISH JOURNAL OF SURGERY (2015)

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Article Gastroenterology & Hepatology

Clinical practice guidelines for the management of biliary tract cancers 2015: the 2nd English edition

Masaru Miyazaki et al.

JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES (2015)

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Article Gastroenterology & Hepatology

Tumour size over 3 cm predicts poor short-term outcomes after major liver resection for hilar cholangiocarcinoma. By the HC-AFC-2009 group

Jean Marc Regimbeau et al.

HPB (2015)

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Article Gastroenterology & Hepatology

Hilar Cholangiocarcinoma: expert consensus statement

John C. Mansour et al.

HPB (2015)

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Review Gastroenterology & Hepatology

Liver transplantation for cholangiocarcinoma: Current status and new insights

Gonzalo Sapisochin et al.

WORLD JOURNAL OF HEPATOLOGY (2015)

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Article Gastroenterology & Hepatology

A New Clinically Based Staging System for Perihilar Cholangiocarcinoma

Roongruedee Chaiteerakij et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2014)

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Article Biochemistry & Molecular Biology

Diagnosis and treatment of cholangiocarcinoma: A consensus from surgical specialists of China

Jian-qiang Cai et al.

JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES (2014)

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Article Surgery

Correlation of staging systems to survival in patients with resected hilar cholangiocarcinoma

Victor M. Zaydfudim et al.

AMERICAN JOURNAL OF SURGERY (2013)

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Review Gastroenterology & Hepatology

Pathogenesis, Diagnosis, and Management of Cholangiocarcinoma

Sumera Rizvi et al.

GASTROENTEROLOGY (2013)

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Article Gastroenterology & Hepatology

New Staging System and a Registry for Perihilar Cholangiocarcinoma

Michelle L. DeOliveira et al.

HEPATOLOGY (2011)

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Article Gastroenterology & Hepatology

Clinical significance of serum tumour M2-PK and CA19-9 detection in the diagnosis of cholangiocarcinoma

Y. G. Li et al.

DIGESTIVE AND LIVER DISEASE (2009)

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Article Oncology

Transplantation for Cholangiocarcinoma: When and for Whom?

David J. Rea et al.

SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA (2009)

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Article Gastroenterology & Hepatology

Cholangiocarcinoma and its management

S. A. Khan et al.

GUT (2007)

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Article Immunology

Predictors of disease recurrence following neoadjuvant chemoradiotherapy and liver transplantation for unresectable perihilar cholangiocarcinoma

Julie K. Heimbach et al.

TRANSPLANTATION (2006)

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Article Nutrition & Dietetics

Nutritional risk index predicts a high-risk population in patients with obstructive jaundice

April Clugston et al.

CLINICAL NUTRITION (2006)

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Prognostic influence for hilar cholangiocarcinoma and comparisons of prognostic values of Mayo staging and TNM staging systems

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