Synthesis and Some Properties of 2-Amino-4-aryl-6-hexyl-7-hydroxy-4H-chromene-3-carbonitriles

Three-component condensation of aromatic aldehydes with malononitrile and 4-hexylresorcinol in toluene in the presence of a base leads to the formation of 2-amino-4-aryl-6-hexyl-7-hydroxy-4H-chromene-3-carbonitriles in good yields (79-90%). Structure of the compounds was studied using two-dimensional NMR spectroscopy methods. Bioavailability parameters were predicted in silico, and possible protein targets were predicted by protein-ligand docking.

Automated summary

In this study, 2-amino-4-aryl-6-hexyl-7-hydroxy-4H-chromene-3-carbonitriles were synthesized in good yields through the three-component condensation of aromatic aldehydes with malononitrile and 4-hexylresorcinol in toluene in the presence of a base. The structure of the compounds was studied using two-dimensional NMR spectroscopy methods. The bioavailability parameters were predicted in silico, and possible protein targets were predicted by protein-ligand docking.