Association between Tumor Necrosis Factor-α Receptor Gene Polymorphism and Ankylosing Spondylitis in Han Population

Objective: To investigate the correlation between tumor necrosis factor-alpha receptor gene polymorphism and ankylosing spondylitis (AS) in Han population. Methods: This study matched 200 Han AS patients admitted to our hospital from March 2014 to March 2020 with 240 healthy controls during the same period. Ligase detection polymerase chain reaction (LDR-PCR) was used to detect TNFRSF1A gene +36A/G (rs767455) site and -383A/C (rs2234649) site, TNFRSF1B gene +196T/G (rs1061622) site single nucleotide polymorphism (SNP) in both groups of patients. Results: The distribution frequency of A allele and G allele at rs767455 of TNFRSF1A gene were different in the AS patients and healthy controls (p < 0.05). The GG genotype and the AA genotype were combined into a homozygous group, and the distribution frequencies of homozygous and heterozygous types between the two groups were statistically significant (p < 0.05). There was no significant difference in the SNPs at rs2234649 of the TNFRSF1A gene and rs1061622 of the TNFRSF1B gene between the AS group and the control group (p > 0.05). Conclusions: The distribution frequency of rs767455 heterozygous (AG) was statistically higher in the AS group, while there was no significant difference in genotype distribution of rsl061622 and rs2234649 between the two group. SNPs in the TNFRSF1A and TNFRSF1B genes were not associated with TNF-alpha antagonist effectiveness.

Automated summary

This study investigates the correlation between tumor necrosis factor-alpha receptor gene polymorphism and ankylosing spondylitis (AS) in the Han population. The results show that TNFRSF1A gene polymorphism is associated with the occurrence of AS in the Han population, while TNFRSF1B gene polymorphism is not. Additionally, a significant genotype difference is found at the rs767455 site of the TNFRSF1A gene.