Comparison of Outcomes of Mild and Severe Community- and Hospital-Acquired Acute Kidney Injury

Purpose: Acute kidney injury (AKI) has shown an increasingly common occurrence among hospitalized patients worldwide. We determined the incidence and compared the short- and long-term outcomes of all stages of community-acquired AKI (CA-AKI) and hospital-acquired AKI (HA-AKI), and identified predictors for such outcomes. Materials and Methods: This observational, single-center, retrospective study identified patients admitted between January 2013 and December 2013 who developed CA-AKI or HA-AKI. Short- and long-term patient and renal outcomes were analyzed. Results: AKI incidence was 14.3% (1882, CA-AKI 4.8% and HA-AKI 9.5%). The highest 30-day and 1-year mortality were recorded in the CA-AKI group. Thirty-day mortality rate was 11.4% in CA-AKI group and 5.7% in HA-AKI group (p<0.001). One-year mortality rates were 20.1% and 13.3%, respectively (p<0.001). More CA-AKI patients developed kidney failure with replacement therapy within 1 year (27, 4.3% vs. 18, 1.4% respectively, p<0.001). Conclusion: In conclusion, patients with CA-AKI had worse short- and long-term outcomes compared to HA-AKI patients. AKI severity and discharge serum creatinine were significant independent predictors of 30-day and 1-year mortality.

Automated summary

Acute kidney injury (AKI) is becoming increasingly common among hospitalized patients worldwide. Community-acquired AKI (CA-AKI) and hospital-acquired AKI (HA-AKI) have different incidence rates, with CA-AKI patients experiencing worse short- and long-term outcomes. CA-AKI patients have higher 30-day and 1-year mortality rates, and a greater number of patients develop kidney failure requiring replacement therapy.