4.3 Article

The Value of Combined Detection of Megakaryocyte and Platelet Parameters for the Diagnosis of Primary Immune Thrombocytopenia

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Hematology

Splenectomy for primary immune thrombocytopenia revisited in the era of thrombopoietin receptor agonists: New insights for an old treatment

Arthur Mageau et al.

Summary: Although the use of splenectomy has declined in recent years, it remains an effective treatment option for adult primary ITP patients who do not respond to TPO-RAs and rituximab. Some patients may experience relapse after splenectomy, but re-challenging with TPO-RAs can result in sustained response for some individuals.

AMERICAN JOURNAL OF HEMATOLOGY (2022)

Review Medicine, General & Internal

Primary Immune Thrombocytopenia: Novel Insights into Pathophysiology and Disease Management

Anurag Singh et al.

Summary: Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by significantly reduced platelet counts in the blood circulation. The complexity of the etiology and heterogeneity of patient characteristics make it challenging for clinicians to choose appropriate therapeutic regimens, emphasizing the importance of considering individual patient factors and preferences in treatment decisions.

JOURNAL OF CLINICAL MEDICINE (2021)

Article Medicine, Research & Experimental

Regulation of Th1/Th2 and Th17/Treg by pDC/mDC imbalance in primary immune thrombocytopenia

Qinzhi Li et al.

Summary: The imbalance of pDC/mDC and the increase of IL-6, IL-12, and IL-23 may lead to the increased differentiation of CD4+ T cells into Th1 and Th17 cells, affecting the balance of Th1/Th2 and Th17/Treg in ITP patients.

EXPERIMENTAL BIOLOGY AND MEDICINE (2021)

Article Hematology

Differential effects of Huaier aqueous extract on human CD4+ T lymphocytes from patients with primary immune thrombocytopenia

Bo Yuan et al.

Summary: The study found that Huaier can suppress the proliferation of immune cells, attenuate the activation of CD4(+) T cells in ITP patients, correct the imbalance of Th1/Th2 polarization, and inhibit the secretion of pro-inflammatory factors. Additionally, it can suppress Treg activity, promote Th17 cell differentiation, and does not affect the levels of IL-10 and transforming growth factor-beta.

EXPERIMENTAL HEMATOLOGY (2021)

Article Cell Biology

Bone marrow mesenchymal stem cell-derived exosomes induce the Th17/Treg imbalance in immune thrombocytopenia through miR-146a-5p/IRAK1 axis

Yue He et al.

Summary: The study demonstrates that exosomal miR-146a-5p derived from BMSCs can regulate Th17/Treg imbalance in ITP by repressing IRAK1 expression, suggesting it as a potential therapeutic target for ITP.

HUMAN CELL (2021)

Article Hematology

Effectiveness and safety of romiplostim among patients with newly diagnosed, persistent and chronic ITP in routine clinical practice in central and Eastern Europe: an analysis of the PLATON study

Barbara Skopec et al.

Summary: This study assessed the effectiveness and safety of romiplostim in different types of ITP patients, finding consistent platelet responses across different durations of ITP and low incidence of adverse drug reactions. The results support the utilization of romiplostim in patients with newly diagnosed and persistent ITP.

HEMATOLOGY (2021)

Review Hematology

Diagnosing Immune Thrombocytopenia

Ulrich J. Sachs

HAMOSTASEOLOGIE (2019)

Review Hematology

A critical appraisal of the evidence for the role of splenectomy in adults and children with ITP

Francesco Rodeghiero

BRITISH JOURNAL OF HAEMATOLOGY (2018)

Article Hematology

Chinese guidelines for treatment of adult primary immune thrombocytopenia

Xin-guang Liu et al.

INTERNATIONAL JOURNAL OF HEMATOLOGY (2018)

Review Immunology

Emerging Concepts in Immune Thrombocytopenia

Maurice Swinkels et al.

FRONTIERS IN IMMUNOLOGY (2018)

Review Immunology

Pathogenesis of immune thrombocytopenia

Sylvain Audia et al.

AUTOIMMUNITY REVIEWS (2017)