期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
卷 18, 期 12, 页码 4756-4767出版社
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.72461
关键词
COVID-19; SARS-CoV-2; MAFLD; NAFLD; Liver injury
资金
- National Natural Science Foundation of China [81672603, 81401978]
- University of Macau [SRG2021-00008-FHS]
- Macao Science and Technology Development Fund grant [0011/2019/AKP]
COVID-19, caused by SARS-CoV-2, has had a detrimental impact on global health and economy. Its association with MAFLD has become a topic of interest, as MAFLD is a potential risk factor for severe COVID-19 symptoms. This review provides an update on the interactions between COVID-19 and MAFLD.
COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become an ongoing global health pandemic. Since 2019, the pandemic continues to cast a long shadow on all aspects of our lives, bringing huge health and economic burdens to all societies. With our in-depth understanding of COVID-19, from the initial respiratory tract to the later gastrointestinal tract and cardiovascular systems, the multiorgan involvement of this infectious disease has been discovered. Metabolic dysfunction-associated fatty liver disease (MAFLD), formerly named nonalcoholic fatty liver disease (NAFLD), is a major health issue closely related to metabolic dysfunctions, affecting a quarter of the world's adult population. The association of COVID-19 with MAFLD has received increasing attention, as MAFLD is a potential risk factor for SARS-CoV-2 infection and severe COVID-19 symptoms. In this review, we provide an update on the interactions between COVID-19 and MAFLD and its underlying mechanisms.
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