Chlorogenic acid intake guidance: Sources, health benefits, and safety

Chlorogenic acid (CGA) is widely present in plant foods and has attracted much attention due to biological activi-ties such as those which are antioxidant, anti-inflammatory, antibacterial, and antiviral. It plays a role in regulat-ing glucose and lipid metabolism, improving insulin resistance, and reducing the risk of type 2 diabetes and car-diovascular diseases. The estimated dietary intake of CGA is 5 to 1000 mg/d. Based on the data from population intervention studies, daily oral doses of CGA at 13.5mg to 1200 mg can reduce fasting blood glucose (FBG), im-prove glucose tolerance, enable weight loss /prevent weight gain, and improve blood pressure in hypertensive pa-tients. Daily intake of 200 mg or more may reduce FBG, with a dose-effect relationship in the range 13.5-500 mg/d. Therefore, a specific proposed level (SPL) of CGA to improve FBG could be >= 200 mg/d. Data insufficien-cy does not allow formulation of a tolerable upper intake level (TUIL) for CGA.

Automated summary

Chlorogenic acid (CGA), widely present in plant foods, has biological activities such as antioxidant, anti-inflammatory, antibacterial, and antiviral effects, and plays a role in regulating glucose and lipid metabolism, improving insulin resistance, and reducing the risk of diabetes and cardiovascular diseases. Intake of 200 mg or more of CGA daily can improve fasting blood glucose levels.