Blood-derived miRNA levels are not correlated with metabolic or anthropometric parameters in obese pre-diabetic subjects but with systemic inflammation (vol 17, e0263479, 2022)

Summary: This study investigates the potential use of blood-derived miRNAs to monitor the effects of a lifestyle intervention to prevent diabetes development in obese Asian Indian pre-diabetic patients. The results show that certain miRNAs are modulated by the intervention and correlated with metabolic improvement, but the positive effects decline after 8 months post-intervention. However, the levels of certain miRNAs and inflammatory markers continue to be modified, indicating a potential link between miRNA levels and systemic inflammation.