期刊
CURRENT ORGANIC CHEMISTRY
卷 26, 期 24, 页码 2203-2213出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1385272827666230217090408
关键词
N; O-acetals; hetero-Diels-Alder (hetero-DA); multicomponent domino reaction (MCR); hydroxyl groups; cyclic enamines; cycloaddition
This mini-review provides a summary of the synthetic progress of fused bicyclic N,O-acetals. Different reaction types, including hetero-Diels-Alder cycloaddition, step-by-step reactions, [3+2] cycloaddition, and other novel strategies, are elaborated. The catalytic systems and reaction mechanisms are also described in detail.
Owing to the prevalent occurring in natural products and abundant bioactivities, the effective synthetic methods of fused bicyclic N,O-acetals skeletons are of great interest to chemists. This mini-review summarized the thus far synthetic progress of fused bicyclic N,O-acetals. These works were elaborated according to the different reaction types, including a) hetero-Diels-Alder cycloaddition of cyclic enamines with oxadienes; b) step-by-step reactions between cyclic enamines and electrophiles with pendant hydroxyl groups; c) [3+2] cycloaddition of indole with quinone or its equivalent and d) other novel strategies. The catalytic systems and reaction mechanisms are mainly described.
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