Effect of bevacizumab plus paclitaxel and carboplatin regimen on prognostic survival of ovarian cancer patients

Objective: To investigate the efficacy of bevacizumab, paclitaxel and carboplatin in the treatment of ovar-ian cancer (OC) and the impact on patients' prognosis. Methods: A total of 90 patients with OC treated at our institution were enrolled in this retrospective analysis. Among them, 30 patients treated with bevacizumab plus paclitaxel and carboplatin regimen were classified as an observation group (OG), and 60 other patients who re-ceived paclitaxel and carboplatin were assigned as a control group (CG). The changes of carbohydrate antigen 199 (CA199), carcinoembryonic antigen (CEA) and carcinoembryonic antigen 242 (CA242) were observed before and after treatment in both groups. The clinical efficacy was observed, and the patients were followed up for 3 years to observe their survival and the adverse effects. Independent factors affecting patient's prognosis were evaluated by Cox regression analysis. Results: After treatment, the objective remission rate and disease control rate were mark-edly higher in the OG than those in the CG (P<0.05). The serum CA199, CEA and CA242 levels of patients in the OG were dramatically lower than those in the CG after chemotherapy (P<0.05). There was no statistically significant difference in the incidence of leukopenia, hemoglobin reduction, neutropenia, gastrointestinal reactions, abnormal renal function and abnormal liver function between the two groups (P>0.05). Cox regression analysis identified that the degree of differentiation, International Federation of Gynecology and Obstetrics stage, CA199 and treatment regimen were independent factors affecting the prognosis of patients (P<0.05). Conclusion: Combined treatment of bevacizumab plus paclitaxel and carboplatin improved the treatment outcome and reduced the levels of CA199, CEA and CA242 in OC without increasing the incidence of adverse events.

Automated summary

This study aimed to investigate the efficacy of bevacizumab, paclitaxel, and carboplatin in the treatment of ovarian cancer and their impact on patients' prognosis. The results showed that the combination treatment significantly improved the objective remission rate, disease control rate, and reduced the levels of CA199, CEA, and CA242 without increasing the incidence of adverse events.