Comparison of post-COVID symptoms in patients with different severity profiles of the acute disease visited at a rehabilitation unit

Article Immunology

Comprehensive Health Assessment 3 Months After Recovery From Acute Coronavirus Disease 2019 (COVID-19)

Bram van den Borst et al.

Summary: This study conducted a comprehensive health assessment on recovered COVID-19 patients from Radboud University Medical Center, Nijmegen, the Netherlands, and found severe problems in multiple health domains. The research revealed that a significant number of discharged patients experienced lung function abnormalities, residual pulmonary parenchymal abnormalities, low exercise capacity, mental and cognitive issues, as well as fatigue. Longer follow-up studies are needed to understand natural trajectories and predictors of complicated long-term recovery paths.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Medicine, General & Internal

6-month consequences of COVID-19 in patients discharged from hospital: a cohort study (Publication with Expression of Concern. See vol. 401, pg. 90, 2023)

Chaolin Huang et al.

Summary: This study aimed to investigate the long-term health consequences of discharged COVID-19 patients and associated risk factors, particularly disease severity. Patients with more severe illness during hospitalization showed more severe impaired pulmonary diffusion capacities and abnormal chest imaging manifestations, highlighting the need for targeted interventions for long-term recovery.

LANCET (2021)

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Article Medicine, General & Internal

Inspiratory muscle training for recovered COVID-19 patients after weaning from mechanical ventilation A pilot control clinical study

Ahmed M. Abodonya et al.

Summary: This study evaluated the effectiveness of inspiratory muscle training (IMT) on recovered COVID-19 patients after being weaned from mechanical ventilation, indicating that IMT can improve pulmonary functions, dyspnea, functional performance, and quality of life, particularly beneficial for ICU patients.

MEDICINE (2021)

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Article Multidisciplinary Sciences

High-dimensional characterization of post-acute sequelae of COVID-19

Ziyad Al-Aly et al.

Summary: This study comprehensively describes the post-acute sequelae of COVID-19 using national healthcare databases, finding increased risk of death and use of health resources beyond the first 30 days of illness, as well as incident sequelae in various organ systems, increased use of therapeutic agents, and evidence of laboratory abnormalities. The findings show a risk gradient according to the severity of acute COVID-19 infection and highlight the burden of health loss experienced by patients who survive the acute phase.

NATURE (2021)

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Article Multidisciplinary Sciences

Pulmonary function and six-minute-walk test in patients after recovery from COVID-19: A prospective cohort study

Dararat Eksombatchai et al.

Summary: The study found that 17.2% of COVID-19 survivors have abnormal spirometry, including restrictive and obstructive defects. Severe COVID-19 pneumonia patients had higher prevalence rates of abnormal spirometry and residual fibrosis on chest radiographs compared to patients with mild symptoms and non-severe pneumonia.

PLOS ONE (2021)

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Article Clinical Neurology

Diaphragm dysfunction in severe COVID-19 as determined by neuromuscular ultrasound

Ellen Farr et al.

Summary: Many survivors of severe COVID-19 experience persistent dyspnea and fatigue even after recovering from the active infection. A study on 21 post-COVID-19 survivors revealed that 76% of them had sonographic abnormalities in diaphragm muscle structure or function, leading to reduced diaphragm muscle contractility compared to non-COVID-19 cohorts. These findings suggest that neuromuscular respiratory dysfunction may contribute to prolonged functional impairments in post-COVID-19 patients after hospitalization.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2021)

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Article Respiratory System

Descriptive analysis of long COVID sequelae identified in a multidisciplinary clinic serving hospitalised and non-hospitalised patients

Stine Johnsen et al.

Summary: The study found that three months after COVID-19 infection, patients still exhibited persistent symptoms and various abnormalities in respiratory, pulmonary, cardiac, physical, and cognitive aspects, which were more pronounced in hospitalized patients. The findings emphasize the importance of multidimensional management strategies in these patients.

ERJ OPEN RESEARCH (2021)

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Article Sport Sciences