期刊
CELL REPORTS METHODS
卷 2, 期 9, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.crmeth.2022.100296
关键词
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资金
- National Institute of Mental Health under Conte Center Grant on the Neurocircuitry of OCD [MH106435, R01MH110594, R01MH116937]
- Army Research Office [78259-NS-MUR]
- McKnight Foundation [R01NS106953]
Neuroeconomics investigates the impact of reward and punishment values on decision-making, but little is known about the influence of noxious experiences on decisions. In this study, researchers used laser stimulation to investigate how neurons in the orbitofrontal cortex encode the value of rewards and punishments. They found that some neurons integrated positive reward value with the negative value of aversive laser stimulation, suggesting a role for the orbitofrontal cortex in more complex decision-making than previously thought.
Neuroeconomics studies how decision-making is guided by the value of rewards and punishments. But to date, little is known about how noxious experiences impact decisions. A challenge is the lack of an aversive stimulus that is dynamically adjustable in intensity and location, readily usable over many trials in a single experimental session, and compatible with multiple ways to measure neuronal activity. We show that skin laser stimulation used in human studies of aversion can be used for this purpose in several key animal models. We then use laser stimulation to study how neurons in the orbitofrontal cortex (OFC), an area whose many roles include guiding decisions among different rewards, encode the value of rewards and punishments. We show that some OFC neurons integrated the positive value of rewards with the negative value of aversive laser stimulation, suggesting that the OFC can play a role in more complex choices than previously appreciated.
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