3.9 Article

Thicker macula in asymptomatic APOE σ4 middle-aged adults at high AD risk

出版社

WILEY
DOI: 10.1002/dad2.12275

关键词

Alzheimer's disease; apolipoprotein E sigma 4 genotype; high risk for Alzheimer's disease; offspring of Alzheimer's disease patients; optical coherence tomography; retinal biomarkers; retinal layers; retinal sectors

资金

  1. Israel Science Foundation [1845/16]
  2. National Network of Excellence (NNE) [PO AG10077820]
  3. Bader Philanthropies
  4. LeRoy Schecter Foundation

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This study compared the retinal layers' thickness between apolipoprotein E (APOE) sigma 4 carriers and non-carriers, and found that asymptomatic midlife APOE sigma 4 carriers at high Alzheimer's disease (AD) risk have thicker macular layers.
Introduction: We compared retinal layers' thickness between apolipoprotein E (APOE) sigma 4 carriers and non-carriers in a cohort of cognitively normal middle-aged adults enriched for Alzheimer's disease (AD) risk. Methods: Participants (N = 245) underwent spectral domain optical coherence tomography. Multivariate analyses of covariance adjusting for age, sex, education, and best corrected vision acuity was used to compare retinal thickness between APOE groups. Results: Participants' mean age was 59.60 (standard deviation = 6.42) with 66.4% women and 32.2% APOE sigma 4 carriers. Greater macular full thickness was observed in APOE sigma 4 carriers compared to non-carriers (P = .017), reaching statistical significance for the inner and outer nasal (P = .009 and P = .005, respectively), inner superior (P = .041), and inner and outer inferior (P = .013 and P = .033, respectively) sectors. The differences between APOE groups were mainly driven by the ganglion cell layer (P < .05) and the inner plexiform layer (P < .05). Discussion: A thicker macula is observed already in midlife asymptomatic APOE sigma 4 carriers at high AD risk.

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