期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 4, 期 17, 页码 2887-2894出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6tb00438e
关键词
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资金
- Natural Science Foundation of China [21475057, 21335004]
- Program for New Century Excellent Talents in University [NCET-12-0256]
- Deanship of Scientific Research at King Saud University [PRG-1437-32]
A novel multifunctional nanoplatform was designed based on the combination of silver nanoparticles (AgNPs) with nucleolin-targeted and doxorubicin (Dox)-loaded manganese dioxide (MnO2) nanosheets to induce enhanced cancer cell apoptosis. MnO2 nanosheets fabricated on the surface of AgNPs served as efficient fluorescence quenchers of Dox. After being internalized into cancer cells, the fluorescence of Dox could be turned on gradually by intracellular glutathione (GSH) which reduces MnO2 into Mn2+ to release Dox. The synergetic effects of AgNP-induced apoptosis and subsequent Dox delivery resulted in enhanced cancer cell apoptosis. Annexin V-FITC/PI double staining, mitochondrial membrane potential (MMP) detection and reactive oxygen species (ROS) detection demonstrated the specific enhanced apoptosis of cancer cells. In this way, the novel nanoprobes can be used as promising theranostic agents for specific cancer therapy.
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