期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 4, 期 21, 页码 3660-3669出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5tb02704g
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资金
- National Natural Science Foundation of China [81503017]
- Natural Science Foundation of Jiangsu Province [BK20150534]
- Senior Talent Foundation of Jiangsu University [14JDG181]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- China Postdoctoral Science Foundation [2015M580404]
- Jiangsu Planned Projects for Postdoctoral Research Funds [1402075B]
To improve the therapeutic effect and decrease the toxicity in normal tissues, stimuli-responsive drug delivery systems have attracted extensive attention in tumor therapy. In this work, we present a smart drug delivery system based on the stimulated decomposition of a thermo-sensitive molecule, azobis[N-(2-carboxyethyl)-2-methylpropionamidine] (Azo), for the combined photothermal therapy and chemotherapy. Doxorubicin (DOX) was attached to the surface of magnetic nanoparticles (NPs) via the Azo linker. Upon irradiation with near infrared (NIR) light, local heating is generated by iron oxide nanoparticles (IONPs), which triggers the decomposition of the Azo molecule and the release of DOX. Compared with Fe3O4-DOX NPs, Fe3O4-Azo-DOX NPs demonstrate dominant advantages of stability, which results in the low toxicity of Fe3O4-Azo-DOX NPs in cardiac tissues. Fe3O4-Azo NPs display excellent photothermal effects under NIR laser irradiation and extremely low cytotoxicity towards MCF-7 cells. Furthermore, the Fe3O4-Azo-DOX NP system exhibits significantly enhanced cell killing effects upon irradiation with NIR, attributed to the synergistic therapeutic efficacy of photothermal chemotherapy.
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