期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 4, 期 37, 页码 6175-6182出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6tb01812b
关键词
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资金
- Research Council of Norway through the FRINATEK program [214607]
- Research Council of Norway through the Norwegian Micro- and Nano-Fabrication Facility, NorFab
Currently there are limitations to gelation strategies to form ionically crosslinked hydrogels, derived in particular from a lack of control over the release kinetics of crosslinking ions, which severely restrict applications. To address this challenge, we describe a new approach to form hydrogels of ionotropic polymers using competitive displacement of chelated ions, thus making specific ions available to induce interactions between polymer chains and form a hydrogel. This strategy enables control of ion release kinetics within an aqueous polymer solution and thus control over gelation kinetics across a wide range of pH. The described technique simplifies or facilitates the use of ionotropic hydrogels in a range of applications, such as 3D printing, microfluidic-based cell encapsulation, injectable preparations and large scale bubble and solid free mouldable gels. We investigate a range of chelator-ion combinations and demonstrate this powerful method to form hydrogels across a wide range of pH and mm-cm length scales. We highlight our findings by applying this gelation strategy to some of the more challenging hydrogel application areas using alginate and polygalacturonate as model polymer systems.
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