期刊
GREEN SYNTHESIS AND CATALYSIS
卷 3, 期 4, 页码 377-379出版社
KEAI PUBLISHING LTD
DOI: 10.1016/j.gresc.2022.03.009
关键词
Alkenes; Alkynylation; Asymmetric catalysis; Nickel; Nickel-hydride
资金
- Natural Science Foundation of Jiangsu Province [BK20190281]
An enantioselective NiH-catalyzed hydroalkynylation of α,β-unsaturated amides is described, which can proceed under mild conditions and is applicable to a wide range of substrates.
An enantioselective NiH-catalyzed hydroalkynylation of & alpha;,fl-unsaturated amides is reported. A wide range of & alpha;,fl-unsaturated amides and bromoalkynes are suitable substrates for this reaction, which proceeds under mild conditions, allowing access to a variety of enantioenriched chiral fl-alkynyl amides. fl,& gamma;-Unsaturated amides can also be used as substrates and undergo the fl-selective hydroalkynylation with a slightly lower enantiomeric excess.
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