期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 4, 期 41, 页码 6620-6639出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6tb01462c
关键词
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资金
- National Natural Science Foundation of China [21231007, 21572282]
- 973 Program [2014CB845604]
- Ministry of Education of China [IRT1298, 313058]
- Guangdong Provincial Government [2013B051000047, 20130501c, 207999]
- Fundamental Research Funds for the Central Universities
- National Science Foundation [CHE-1213673, CHE-1156836]
- National Institute of Health [RR028992]
RNA interference (RNAi) is a naturally occurring endogenous regulatory process in which the short double-stranded RNA causes sequence-specific post-transcriptional gene silencing. Small interfering RNA (siRNA) represents great therapeutic potential for diseases (e.g., cancer) caused by abnormal gene overexpression or mutation. The major challenge in using RNAi for disease therapy is the targeted and effective delivery of siRNA in vivo. The development of nanotechnology with the important progress in nanoparticle-mediated delivery systems promises efficient intracellular siRNA delivery. This review summarizes the recent advances in nanoparticle delivery systems for siRNA-based therapeutics.
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