期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 4, 期 14, 页码 2498-2511出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6tb00117c
关键词
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资金
- National Basic Research Program of China [2012CB619102]
- National Natural Science Foundation of China [31370954, 51431002]
- Project of Scientific and Technical Plan of Beijing [Z141100002814008]
- China Scholarship Council (CSC) [201506010201]
The design of functional biomaterials that respond intelligently to external stimuli has become a rapidly growing area with widespread interest. This work contributes to the development of a feedback-active anticorrosion system with intriguing self-healing ability to protect magnesium (Mg) from biocorrosion. The system was constituted by an inner micro/nano-porous, ceramic-like pre-coating developed readily from the substrate, and an outermost inhibitor (nanosized cerium (Ce) oxides) containing chitosan (CS) multilayers. Here, the pre-coating acted as both an anchoring'' and a barrier'' layer to acquire structural integrity and improved impedance, respectively. Green CS served as cargo for Ce to be entrapped, harnessing Ce-NH2 complexation chemistry. The coating barrier properties were evaluated by electrochemical impedance spectroscopy. The active corrosion inhibition was assessed by immersion degradation tests with respect to Mg2+ release, pH alteration, crack development, and scanning Kelvin potential. To our delight, the coatings effectively protected the substrate from biocorrosion in vitro compared with bare alloys. Putatively, the pH-triggered formation of Ce oxide precipitation, along with the pH-buffering activity and movable swelling capacity of CS macromolecules, should have contributed to restraining the anodic activity and healing the cracks/defects dynamically. Furthermore, the coated substrate had the biocompatibility to elicit better attachment and growth of osteoblasts.
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