期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 4, 期 32, 页码 5446-5454出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6tb01224h
关键词
-
资金
- National Natural Science Foundation of China [21420102006, 21273136]
DNA microgels of oligonucleotides and polymers were constructed via a combination of DNA complementarity and photo-initiated free radical polymerization. The DNA microgels did not feature the conventional core-shell structure but were instead based on the copolymers of N-isopropylacrylamide and acrylamide and DNA crosslinks. By incorporating the aptamer-functionalized moieties, the AptMG-Dox system was demonstrated to possess excellent biocompatibility and highly selective killing efficacy for target cancer cells via stimuli-responsiveness, which could provide immense potential as an intelligent drug delivery carrier for targeted cancer therapy.
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