期刊
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
卷 56, 期 4, 页码 401-417出版社
Cell Physiol Biochem Press GmbH & Co
DOI: 10.33594/000000559
关键词
Heart; Myocardial injury; Doxorubicin; Oxidative stress
资金
- CMHS [NP-18-29]
- Zayed Bin Sultan Center for Health Sciences (ZCHS) [21RO73]
Doxorubicin is a potent chemotherapeutic drug, but its usage is limited due to serious side effects, especially cardiotoxicity. Nootkatone has been found to improve Doxorubicin-induced myocardial injury through modulation of NF-kappa B signals and reduction of oxidative stress.
Background/Aims: Doxorubicin (DOXO) is a potent chemotherapeutic drug that is used in the treatment of a large number of cancers. Despite its important chemotherapeutic characteristics, its usage is limited because of the serious side effects; the most noticeable is cardiotoxicity which can manifest acutely or years after completion of treatment leading to left ventricular dysfunction, dilated cardiomyopathy and heart failure. Nootkatone (NK) is a recognized bioactive compound isolated from the heartwood of Cupressus nootkatensis and has been reported to have antiseptic, antioxidant, and anti-allergic activities. Methods: Male C57B6/J mice were used for mice model of DOXO-cardiac toxicity. Mice were given either DOXO or NK or DOXO+NK or vehicle (normal saline) after which the mice again had free access to food and water. Heart and plasma samples were collected 5 days after DOXO administration and were used for immunohistochemistry, electron microscopy and enzyme linked immunosorbent assay (ELISA). Results: There were significant reduction in inflammatory markers in hearts of DOXO-NK- treated mice when compared with DOXO-treated mice. Moreover, there were significant increase in antioxidant proteins and reduction of oxidative stress in hearts of DOXO-NK-treated mice when compared with DOXO-treated mice. There was a significant reduction in myocardial damage as shown by significant reduction of troponin I in DOXO-NK- treated mice when compared with DOXO-treated mice. Conclusion: Nootkatone improves DOXO-induced myocardial injury through modulation of NF-kappa B signals and reduction of oxidative stress. (c) 2022 The Author(s). Published by Cell Physiol Biochem Press GmbH&Co. KG
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据