期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 10, 期 48, 页码 9984-9991出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2tb01819e
关键词
-
资金
- PAPIIT UNAM, Mexico [IN205320]
- PAPIIT-UNAM, Mexico [IN202820]
Linezolid (LNZ), a new-generation synthetic molecule, is being explored for antibacterial treatment, with research focusing on its release within MOFs (MOF-74(Zn) and MOF-74(Cu)) as a potential antimicrobial system for combating antimicrobial resistance.
Linezolid (LNZ) is a new-generation synthetic molecule for the antibacterial treatment of severe infections, particularly in infective cases where the bacterial resistance to first-choice drugs is caused by Gram-positive pathogens. In this context, since 2009, some strains resistant to LNZ in patients with long-term treatments have been reported. Therefore, there is a need to use not only new drug molecules with antibacterial activities in the dosage form but also a different approach to pharmacotherapeutic strategies for skin infections, which lead to a reduction in the concentration of biocides. This work explores LNZ hosted at two isostructural MOFs, MOF-74(Zn) and MOF-74(Cu), as promising antimicrobial systems for gradual biocide release within 6 h. These systems reach a lower minimum inhibitory concentration (MIC) in comparison to free LNZ. Even a decreased MIC value is also observed, which is an encouraging result regarding the efficiency of the systems to control concentration-dependent antimicrobial resistance.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据