Catch-enrich-release approach for amine-containing natural products

Amine-containing natural products are an important class of therapeutic compounds. Herein, we report a chemoselective approach to catch and enrich amine-containing natural products, and release them as underivatized compounds. The strategy exploits the selectivity of the enzyme legumain for the specific release of amine-containing natural products.

Automated summary

This paper reports a chemoselective approach to catch and enrich amine-containing natural products, releasing them as underivatized compounds.