4.7 Article

Design, Synthesis, Biological Activity, and Structural Analysis of Novel Des-C-Ring and Aromatic-D-Ring Analogues of 1α,25

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Oncology

An update on vitamin D signaling and cancer

Carsten Carlberg et al.

Summary: A low vitamin D status is associated with an increased risk of various cancers. The biologically active form of vitamin D, 1,25(OH)2D3, influences the epigenome and transcriptome of healthy and neoplastic cells, affecting their growth and differentiation.

SEMINARS IN CANCER BIOLOGY (2022)

Article Biochemistry & Molecular Biology

POU1F1 transcription factor induces metabolic reprogramming and breast cancer progression via LDHA regulation

Anxo Martinez-Ordonez et al.

Summary: Metabolic reprogramming in breast cancer cells and fibroblasts is influenced by the transcription factor POU1F1 through its regulation of the LDHA gene, leading to increased cancer progression.

ONCOGENE (2021)

Review Chemistry, Medicinal

Strategies for the Synthesis of 19-nor-Vitamin D Analogs

Susana Fernandez et al.

PHARMACEUTICALS (2020)

Article Chemistry, Medicinal

Structural Analysis of VDR Complex with ZK168281 Antagonist

Anna Y. Belorusova et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

Review Chemistry, Medicinal

Vitamin D and its analogs as anticancer and anti-inflammatory agents

Jingxuan Chen et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

Article Multidisciplinary Sciences

Cytosolic sequestration of the vitamin D receptor as a therapeutic option for vitamin D-induced hypercalcemia

Daniela Rovito et al.

NATURE COMMUNICATIONS (2020)

Article Chemistry, Medicinal

Vitamin D and Its Synthetic Analogs

Miguel A. Maestro et al.

JOURNAL OF MEDICINAL CHEMISTRY (2019)

Review Medicine, General & Internal

Non-Skeletal Activities of Vitamin D: From Physiology to Brain Pathology

Giulia Bivona et al.

MEDICINA-LITHUANIA (2019)

Review Pharmacology & Pharmacy

Update on pharmacologically-relevant vitamin D analogues

Glenville Jones et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2019)

Article Multidisciplinary Sciences

Studies on the Synthesis of Vitamin D Analogs with Aromatic D-Ring

Silvina Eduardo-Canosa et al.

ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS (2018)

Article Chemistry, Medicinal

Aromatic-Based Design of Highly Active and Noncalcemic Vitamin D Receptor Agonists

Pranjal Gogoi et al.

JOURNAL OF MEDICINAL CHEMISTRY (2018)

Review Paleontology

The discovery and synthesis of the nutritional factor vitamin D

Glenville Jones

INTERNATIONAL JOURNAL OF PALEOPATHOLOGY (2018)

Review Biochemistry & Molecular Biology

Vitamins D: Relationship between Structure and Biological Activity

Andrzej Kutner et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Biochemistry & Molecular Biology

Seco-B-Ring Steroidal Dienynes with Aromatic D Ring: Design, Synthesis and Biological Evaluation

Marcin Szybinski et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Biochemistry & Molecular Biology

Regulation of the vitamin D receptor by vitamin D lactam derivatives

Lisa Asano et al.

FEBS LETTERS (2016)

Review Physiology

VITAMIN D: METABOLISM, MOLECULAR MECHANISM OF ACTION, AND PLEIOTROPIC EFFECTS

Sylvia Christakos et al.

PHYSIOLOGICAL REVIEWS (2016)

Article Chemistry, Multidisciplinary

New Ways to Boost Molecular Dynamics Simulations

Elmar Krieger et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2015)

Article Biochemical Research Methods

YASARA View-molecular graphics for all devices-from smartphones to workstations

Elmar Krieger et al.

BIOINFORMATICS (2014)

Review Chemistry, Medicinal

Synthesis of 6-s-cis and 6-s-trans A-Ring Modified Vitamin D Analogues

Susana Fernandez et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2014)

Review Chemistry, Medicinal

Retiferols - synthesis and biological activity of a conceptually novel class of vitamin D analogs

Narasimha Rao Bolla et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2014)

Article Chemistry, Organic

Synthesis of 2-Ethyl-19-nor Analogs of 1α,25-Dihydroxyvitamin D3

Duchan R. Laplace et al.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2013)

Article Biochemistry & Molecular Biology

Synthesis of 1α,25-dihydroxyvitamin D3 analogues with α-hydroxyalkyl substituents at C12

Diego M. Carballa et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2013)

Article Endocrinology & Metabolism

The History of the Discovery of Vitamin D and Its Daughter Steroid Hormone

Anthony W. Norman

ANNALS OF NUTRITION AND METABOLISM (2012)

Review Biochemistry & Molecular Biology

A-ring analogs of 1,25-dihydroxyvitamin D3

Agnieszka Glebocka et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2012)

Review Chemistry, Medicinal

Vitamin D receptor ligands: the impact of crystal structures

Carsten Carlberg et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2012)

Article Chemistry, Multidisciplinary

Synthesis of (1a)-1,25-Dihydroxyvitamin D3 with a ß-Positioned Seven-Carbon Side Chain at C(12)

Diego M. Carballa et al.

HELVETICA CHIMICA ACTA (2012)

Article Chemistry, Multidisciplinary

Light-Driven Transport of a Molecular Walker in Either Direction along a Molecular Track

Michael J. Barrell et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)

Article Chemistry, Organic

New C15-Substituted Active Vitamin D3

Kanako Shindo et al.

ORGANIC LETTERS (2011)

Article Chemistry, Medicinal

An o-Aminoanilide Analogue of 1α,25-Dihydroxyvitamin D3 Functions as a Strong Vitamin D Receptor Antagonist

Marc Lamblin et al.

JOURNAL OF MEDICINAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Design and synthesis of active vitamin D analogs

Silvina Eduardo-Canosa et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2010)

Article Biochemistry & Molecular Biology

CD-ring modified vitamin D3 analogs and their superagonistic action

Guy Eelen et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2010)

Article Biochemistry & Molecular Biology

Synthesis of 1α,25-Dihydroxyvitamin D Analogues Featuring a S2-symmetric CD-ring Core

Garrett Minne et al.

MOLECULES (2009)

Article Chemistry, Organic

Synthesis of 22-oxaspiro[4.5]decane CD-ring modified analogs of 1α,25-dihydroxyvitamin D3

Frederik De Buysser et al.

TETRAHEDRON LETTERS (2009)

Article Biochemistry & Molecular Biology

Structure-based design of a superagonist ligand for the vitamin D nuclear receptor

Shinji Hourai et al.

CHEMISTRY & BIOLOGY (2008)

Article Biochemistry & Molecular Biology

Superagonistic Fluorinated Vitamin D3 Analogs Stabilize Helix 12 of the Vitamin D Receptor

Guy Eelen et al.

CHEMISTRY & BIOLOGY (2008)

Review Chemistry, Organic

Enantioselective synthesis of steroids

Anne-Sophie Chapelon et al.

TETRAHEDRON (2007)

Article Biochemistry & Molecular Biology

Removal of C-ring from the CD-ring skeleton of 1α,25-dihydroxyvitamin D3 does not alter its target tissue metabolism significantly

G. Satyanarayana Reddy et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2007)

Article Biochemistry & Molecular Biology

The development of CD-ring modified analogs of 1α,25-dihydroxyvitamin D

Pierre J. De Clercq et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Adaptability of the Vitamin D nuclear receptor to the synthetic ligand Gemini: Remodelling the LBP with one side chain rotation

Fabrice Ciesielski et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2007)

Article Chemistry, Organic

Synthesis of spiro[4.5] decane CF-ring analogues of 1α,25-dihydroxyvitamin D3

Wim Schepens et al.

ORGANIC LETTERS (2006)

Article Chemistry, Medicinal

Novel 1α,25-dihydroxyvitamin D3 analogues with the side chain at C12

XC González-Avión et al.

JOURNAL OF MEDICINAL CHEMISTRY (2006)

Article Chemistry, Organic

The chemistry of alkylstrontium halide analogues, part 2: Barbier-type dialkylation of esters with alkyl halides

N Miyoshi et al.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2005)

Article Endocrinology & Metabolism

Biological activity of CD-Ring modified 1α,25-dihydroxyvitamin D Analogues:: C-ring and five-membered D-Ring analogues

A Verstuyf et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2000)