期刊
BRAIN, BEHAVIOR, & IMMUNITY - HEALTH
卷 26, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbih.2022.100550
关键词
Adversity; Positive experiences; Inflammation; Longitudinal; LSAC; ALSPAC
资金
- UK Medical Research Council (MRC)
- Wellcome [DK077659]
- University of Bristol
- National Institute of Health (NIH) [DK077659]
- MRC [07467/Z/05/Z]
- University College London Global Engagement Award
- Victorian Government's Operational Infrastructure Support Program
- NHMRC Career Development Fellowship [APP1123677]
- UK Economic and Social Research Council grant [ES/P010229/1]
- National Institutes of Health [1R01HL151848-01]
- Australian Research Council Discovery Early Career Award [DE190101326]
- Australian National Health and Medical Research Council (NHMRC) Practitioner Fellowship [1155290]
- NHMRC Investigator Grant [APP1175744]
- Melbourne Children's Life Course initiative
- Royal Children's Hospital Foundation Grant [2018-984]
This study found that adverse experiences in childhood are associated with higher inflammation, while positive experiences are associated with lower inflammation.
Background: The relationship between childhood adversity and inflammation is well-established. Examination of positive experiences can provide a more complete understanding of intervention opportunities. We investigated associations of adverse and positive experiences, and their intersection, with inflammation in children and adolescents.Methods: Data sources: Longitudinal Study of Australian Children (LSAC; N =1237) and Avon Longitudinal Study of Parents and Children (ALSPAC; N = 3488). Exposures: Adverse and positive experiences assessed repeatedly (LSAC: 0-11 years; ALSPAC: 0-15 years). Outcomes: Inflammation quantified by high sensitivity C-reactive protein (hsCRP) and glycoprotein acetyls (GlycA) (LSAC: 11-12 years; ALSPAC: 15.5 years). Analyses: Linear regression on the log-transformed outcomes estimated the relative difference in inflammatory markers with adverse/positive experiences, adjusting for socio-demographics and concurrent positive/adverse experiences, respectively.Results: Most associations were in the expected direction but differed in magnitude by exposure, outcome and cohort. Across both cohorts, adverse experiences were associated with up to 7.3% higher hsCRP (95% CI:-18.6%, 33.2%) and up to 2.0% higher GlycA (95% CI: 0.5%, 3.5%); while positive experiences were associated with up to 22.1% lower hsCRP (95% CI:-49.0%, 4.7%) and 1.3% lower GlycA (95% CI:-2.7%, 0.2%). In LSAC, the beneficial effect of positive experiences on inflammation was more pronounced among those with fewer concurrent adverse experiences.Conclusion: Across two cohorts, we found small but directionally consistent associations between adverse experiences and higher inflammation, and positive experiences and lower inflammation, particularly for GlycA. Future research should give further consideration to positive experiences to complement the current focus on adversity and inform the design and evaluation of early life interventions.
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