3.8 Article

Associations of circulating cell-free DNA, C-reactive protein, and cardiometabolic risk among low-active smokers with elevated depressive symptoms

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ELSEVIER
DOI: 10.1016/j.bbih.2022.100519

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Cell-free DNA; Metabolic syndrome; Cardiometabolic risk; C-reactive protein; Inflammation

资金

  1. National Institute of Mental Health (NIMH) [MH101107]
  2. National Cancer Institute (NCI) [CA173551]
  3. NIMH [MH101076]
  4. Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) [HD101392]

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This study examined the associations between cell-free DNA (cfDNA) and metabolic syndrome risk. The results showed significant associations between cfDNA from the nucleus (cf-nDNA) and C-reactive protein (CRP) with metabolic risk, while cfDNA from the mitochondria (cf-mtDNA) was not significantly associated. This suggests a role for cf-nDNA in inflammatory processes associated with metabolic syndrome, with distinct roles for cf-nDNA and cf-mtDNA.
Background and aims: Cell-free DNA (cfDNA) is elevated in several disease states. Metabolic syndrome is a constellation of factors associated with poor cardiometabolic outcomes. This study examined associations of cfDNA from the nucleus (cf-nDNA) and mitochondria (cf-mtDNA), C-reactive protein (CRP), and metabolic syndrome risk, in low-active smokers with depressive symptoms. Methods: Participants (N = 109; mean age 47) self-reported medical history. Physical activity was determined by accelerometry and anthropometrics were measured. Blood was collected and analyzed for cf-nDNA, cf-mtDNA, CRP, triglycerides, high-density lipoprotein, hemoglobin A1c. A continuous metabolic syndrome composite risk score was calculated. Relationships of cf-nDNA, cf-mtDNA, CRP, and cardiometabolic risk were examined with correlations and linear regression. Results: CRP and cf-nDNA were significantly associated with metabolic syndrome risk (r = .39 and r = .31, respectively), cf-mtDNA was not (r = .01). In a linear regression, CRP and cf-nDNA significantly predicted the metabolic syndrome risk score, findings that remained significant controlling for age, gender, nicotine dependence, and physical activity. Conclusions: Associations of cf-nDNA with both CRP and metabolic risk suggest a role for cf-nDNA in inflammatory processes associated with metabolic syndrome. The negative findings for cf-mtDNA suggest distinct roles for cf-nDNA and cf-mtDNA in these processes.

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