期刊
CLINICAL AND EXPERIMENTAL MEDICINE
卷 23, 期 2, 页码 437-445出版社
SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s10238-022-00822-3
关键词
Gastric cancer; Very young; Clinicopathological characteristics; Prognosis factors
This study explored the clinicopathological characteristics, survival outcomes, and prognosis of very young gastric cancer (GC) patients. The results showed that very young GC patients were predominantly female, with diffuse and poorly differentiated types, and most patients were diagnosed at an advanced stage. The common sites of metastasis were the ovary and peritoneum. TNM stage and radical surgery were identified as independent prognostic factors for the overall survival of very young GC patients.
To explore the clinicopathological characteristics, survival outcomes, and prognosis of very young gastric cancer (GC). From January 1, 2011 to January 1, 2021, GC patients under 30 years old treated in three tertiary hospitals were enrolled. Clinicopathological characteristics were summarized, prognostic factors and survival outcomes including overall survival (OS), disease-free survival (DFS), and progression-free survival (PFS) were retrospectively analyzed. One hundred patients were finally included, with a median age of 23 years.73 (73.0%) were female. Most patients had initial symptoms of abdominal pain (66.0%). The most common tumor locations were gastric antrum (38.0%) and gastric body (37.0%). The main histological types were diffuse (81.0%) and poorly differentiated (91.0%). Most patients presented with stage III-IV disease (82.0%) at diagnosis and the common sites of metastasis were ovary (39.5%) and peritoneum (27.6%). The mOS of the whole group was 23.3 months (95% CI 17.2-29.4). Moreover, the mOS of patients at stage I-II was not reached. The mOS of patients at stage III and stage IV was 40.6 months (95% CI 10.2-70.9) and 10.3 months (95% CI 8.9-11.6), respectively. The mDFS of stage I-III patients was 28.5 months (95% CI 14.7-42.3), and the mPFS of the metastatic patients was 4.5 months (95% CI 4.0-5.0). TNM stage (P = 0.005) and radical surgery (P = 0.001) were independent prognostic factors of overall survival. The very young GC were predominantly female, diffuse type, and advanced diagnosis. TNM stage and radical surgery were independent prognosis factors for overall survival.
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