期刊
JOURNAL OF DIABETES RESEARCH
卷 2016, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2016/6194750
关键词
-
资金
- National Natural Science Foundation of China [81400811]
Objective. To investigate the association between circulating betatrophin level and type 2 diabetes mellitus (T2DM) in human. Methods. A comprehensive literature search was performed in PubMed and Embase databases to identify eligible studies assessing the circulating levels of betatrophin in both T2DM patients and nondiabetic adults. Results. A total of nine eligible studies with twelve comparisons were included for the final meta-analysis. Circulating betatrophin levels in T2DM patients were higher than those in the nondiabetic controls (random-effect SMD 0.53; 95% CI 0.13 to 0.94;P = 0.010). In the subgroup of nonobese population but not the obese population, the overall betatrophin level in T2DM patients was much higher than that in the nondiabetic controls (nonobese: random-effect SMD, 0.82; 95% CI 0.42 to 1.21;P < 0.001; obese: random-effect SMD, -0.39; 95% CI, -0.95 to 0.18;P = 0.18). Metaregression indicated that body mass index of T2DM patients was associated with mean difference of betatrophin level between T2DM and nondiabetic adults (slope, -578.8;t = -2.7;P = 0.02). Conclusion. Based on the findings of our meta-analysis, circulating betatrophin level of T2DM patients is higher than that of nondiabetic adults in the nonobese population, but not in the obese population.
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