3.9 Article

The D allele of angiotensin-converting enzyme gene insertion/deletion polymorphism is associated with the lung involvement in COVID-19

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Virology

Angiotensin-converting-enzyme insertion/deletion polymorphism, ACE activity, and COVID-19: A rather controversial hypothesis. A case-control study

Anna Papadopoulou et al.

Summary: Accumulated data suggests a role of the renin-angiotensin system in COVID-19 pathogenesis, with the ACE insertion/deletion polymorphism potentially increasing the risk for severe disease. A retrospective study found that COVID-19 patients with the DD genotype and D allele carriers had a higher risk of developing severe disease, associated with lower ACE activity. This highlights the need for further research on ACE genotype-based therapies in COVID-19 patients.

JOURNAL OF MEDICAL VIROLOGY (2022)

Review Medical Laboratory Technology

Complete blood count alterations in COVID-19 patients: A narrative review

Mariangela Palladino

Summary: The COVID-19 pandemic has brought about a scientific and social crisis. The clinical course of COVID-19 can have unpredictable outcomes, with various haematological parameters being linked to infection severity. Our understanding of these parameters could help in identifying effective biomarkers for disease progression.

BIOCHEMIA MEDICA (2021)

Article Biochemistry & Molecular Biology

Distribution of the ACE1 D Allele in the Bosnian-Herzegovinian Population and its Possible Role in the Regional Epidemiological Picture of COVID-19

Merisa Cenanovic et al.

Summary: The distribution of the ACE1 D allele in Bosnia and Herzegovina was found to be similar to other European populations, with no significant correlation observed between D allele frequency and COVID-19 incidence, mortality, and case severity across the examined populations.

GENETIC TESTING AND MOLECULAR BIOMARKERS (2021)

Review Peripheral Vascular Disease

ACE gene I/D polymorphism and severity of SARS-CoV-2 infection in hospitalized patients: a meta-analysis

Teodoro J. Oscanoa et al.

Summary: This study conducted a meta-analysis on the association between ACE gene I/D polymorphism and severity of SARS-CoV-2 infection, revealing that patients with the DD genotype have a higher risk of severe COVID-19 during hospitalization. Further studies involving more diverse ethnic groups are needed to fully establish this association.

ARTERIAL HYPERTENSION (2021)

Article Medicine, General & Internal

Angiotensin-converting enzyme-1 gene insertion/deletion polymorphism may be associated with COVID-19 clinical severity: a prospective cohort study

Ozgur Gunal et al.

Summary: The study investigated the relationship between ACE I/D polymorphism and the clinical severity of COVID-19, finding that the ACE II genotype may have a protective effect against severe COVID-19.

ANNALS OF SAUDI MEDICINE (2021)

Article Medical Laboratory Technology

ACE I/D polymorphism in Czech first-wave SARS-CoV-2-positive survivors

Jaroslav A. Hubacek et al.

Summary: This study found that ACE I/D polymorphism has the potential to predict the severity of COVID-19, with I/I homozygotes being at increased risk of symptomatic COVID-19.

CLINICA CHIMICA ACTA (2021)

Article Genetics & Heredity

Relationship between the Prevalence of ACE1 I/D Polymorphism Genotype II and Covid-19 Morbidity, Mortality in Ukraine and in Some Europe Countries

L. A. Livshits et al.

Summary: The genetic characteristics of individuals play an important role in determining resistance or susceptibility to COVID-19. Studies have shown a negative correlation between genotype II (ACE1, I/D polymorphism) and susceptibility to SARS-CoV-2 infection, indicating that individuals with genotype II may be more resistant to the virus. Further research on the role of the ACE1 gene in the severity and complications of COVID-19 patients could lead to the identification of genetic markers for personalized therapy.

CYTOLOGY AND GENETICS (2021)

Article Infectious Diseases

Impact of I/D polymorphism of angiotensin-converting enzyme 1 (ACE1) gene on the severity of COVID-19 patients

Sushma Verma et al.

Summary: The study suggests that the ACE1 genotype may impact the incidence and clinical outcome of COVID-19. DD genotype, frequency of D allele, older age, unmarried status, presence of diabetes and hypertension were significantly higher in severe COVID-19 patients. ACE1 ID genotype was significantly associated with higher socio-economic COVID-19 patients.

INFECTION GENETICS AND EVOLUTION (2021)

Article Virology

Polymorphisms of ACE (I/D) and ACE2 receptor gene (Rs2106809, Rs2285666) are not related to the clinical course of COVID-19: A case study

Sevim Karakas Celik et al.

Summary: In this study, the polymorphisms of ACE gene I/D, ACE2 receptor gene rs2106809, and rs2285666 were not significantly associated with the severity of COVID-19 infection in the study population. While ACE2 receptor gene expression may influence susceptibility to COVID-19, there is no current evidence linking ACE or ACE2 gene polymorphisms directly to COVID-19 severity. Individual differences in COVID-19 severity might be influenced by epigenetic mechanisms of ACE2 receptor gene expression or variations in other genes involved in COVID-19 pathogenesis.

JOURNAL OF MEDICAL VIROLOGY (2021)

Article Peripheral Vascular Disease

Human Ace D/I Polymorphism Could Affect the Clinicobiological Course of COVID-19

Elifcan Aladag et al.

Summary: The study found that the DI genotype of ACE gene I/D polymorphism is associated with the infection rate, particularly severe pneumonia, in COVID-19 immunoinflammatory syndrome. Therefore, ACE D/I polymorphism may affect the clinical course of COVID-19.

JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM (2021)

Article Public, Environmental & Occupational Health

Ethnic Prevalence of Angiotensin-Converting Enzyme Deletion (D) Polymorphism and COVID-19 Risk: Rationale for Use of Angiotensin-Converting Enzyme Inhibitors/Angiotensin Receptor Blockers

Rangaprasad Sarangarajan et al.

Summary: The study suggests a correlation between ACE insertion/deletion polymorphism and COVID-19 infections and comorbidities, with higher frequency of ACE D allele in European, Asian, African, and American populations. ACE DD polymorphism may lead to inflammation, organ damage, and increased risk of COVID-19 infection.

JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES (2021)

Review Pharmacology & Pharmacy

A hypothesis for pathobiology and treatment of COVID-19: The centrality of ACE1/ACE2 imbalance

Krishna Sriram et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

Article Medicine, General & Internal

Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area

Safiya Richardson et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Editorial Material Medical Laboratory Technology

The host's angiotensin-converting enzyme polymorphism may explain epidemiological findings in COVID-19 infections

Joris R. Delanghe et al.

CLINICA CHIMICA ACTA (2020)

Editorial Material Genetics & Heredity

ACE polymorphisms and COVID-19-related mortality in Europe

Matteo Bellone et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2020)

Article Infectious Diseases

Angiotensin converting enzyme genotypes and mortality from COVID-19: An ecological study

Ar K. Aung et al.

JOURNAL OF INFECTION (2020)

Review Biochemistry & Molecular Biology

Therapeutic approaches on the interaction between SARS-CoV2 and ACE2: a biochemical perspective

Gulden Baskol et al.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI (2020)

Review Medicine, Research & Experimental

Laboratory features of severe vs. non-severe COVID-19 patients in Asian populations: a systematic review and meta-analysis

Sulmaz Ghahramani et al.

EUROPEAN JOURNAL OF MEDICAL RESEARCH (2020)