4.7 Article

Integrating supercapacitor with sodium hyaluronate based hydrogel as a novel All-In-One wound Dressing: Self-Powered electronic stimulation

期刊

CHEMICAL ENGINEERING JOURNAL
卷 452, 期 -, 页码 -

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ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2022.139491

关键词

All -in -one; Self -powered electronic stimulated; Supercapacitor; Wound dressing; Sodium hyaluronate; Flexible bioelectronics

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This study introduces a novel all-in-one self-powered electronic stimulated wound dressing, which integrates a supercapacitor with a sodium hyaluronate based hydrogel. The wound dressing is able to perform electrical stimulation without the need for an external power supply, enabling patients to receive treatment anywhere and anytime. The introduction of sodium hyaluronate promotes cell proliferation and accelerates wound healing, while also improving the electrochemical performance of the supercapacitor. This all-in-one wound dressing has excellent mechanical properties, high water absorption capacity, and good biocompatibility, meeting the practical requirements for clinical wound dressings.
Constructing the electron transport pathway in a conductive gel membrane wound dressing could promote wound healing, but it always needs an external power supply that bright much inconvenience in clinical practice. In this paper, we design a novel all-in-one self-powered electronic stimulated wound dressing that integrating supercapacitor with sodium hyaluronate based hydrogel. The supercapacitor layer provides the required continuously electrical energy for the wound-dressing layer, where sodium hyaluronate is used as substrate material in both layers for forming the advanced all-in-one structure. During the course of clinical treatment, the electrical stimulation self-powered by supercapacitor would enable patients to perform electrical stimulation wound treatment anytime and anywhere no need on the back ward of a hospital. At the same time, introducing sodium hyaluronate as the active substance and polyelectrolyte would promote cell proliferation and accelerate wound healing, and improve electrochemical performance of supercapacitors. The all-in-one wound dressing has good mechanical properties, high water absorption capacity, and excellent biocompatibility to meet the practical requirements of clinical wound dressings. The supercapacitor layer in the all-in-one wound dressing has good electrochemical performance for charging and discharging before and after usage for wound treatment, and the wound dressing layer enhances the proliferative activity of NIH3T3 cells and accelerate the wound healing process in mice under the action of electrical stimulation provided by the supercapacitor. This study demon-strates that the all-in-one wound dressing would be an attractive candidate for portable wound healing, and broaden the scope of flexible electronics for biomedical applications.

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