期刊
STEM CELL REVIEWS AND REPORTS
卷 19, 期 2, 页码 322-344出版社
SPRINGER
DOI: 10.1007/s12015-022-10452-7
关键词
Systemic lupus erythematosus; Mesenchymal stem cells; Acquired immune system; Lymphocyte repertoire
The breakdown of self-tolerance in the immune response can cause autoimmune diseases like systemic lupus erythematosus (SLE), which is more prevalent in women of childbearing age and influenced by ethnicity. Dysregulation in B cell subsets and hyperactive T helper cells play a major role in SLE's pathogenesis. New treatment strategies using mesenchymal stem cells (MSCs) as immune modulators show promise in controlling autoimmune responses without suppressing the immune system.
The breakdown of self-tolerance of the immune response can lead to autoimmune conditions in which chronic inflammation induces tissue damage. Systemic lupus erythematosus (SLE) is a debilitating multisystemic autoimmune disorder with a high prevalence in women of childbearing age; however, SLE incidence, prevalence, and severity are strongly influenced by ethnicity. Although the mystery of autoimmune diseases remains unsolved, disturbance in the proportion and function of B cell subsets has a major role in SLE's pathogenesis. Additionally, colocalizing hyperactive T helper cell subgroups within inflammatory niches are indispensable. Despite significant advances in standard treatments, nonspecific immunosuppression, the risk of serious infections, and resistance to conventional therapies in some cases have raised the urgent need for new treatment strategies. Without the need to suppress the immune system, mesenchymal stem cells (MSCs), as smart immune modulators, are able to control cellular and humoral auto-aggression responses by participating in precursor cell development. In lupus, due to autologous MSCs disorder, the ability of allogenic engrafted MSCs in tissue regeneration and resetting immune homeostasis with the provision of a new immunocyte repertoire has been considered simultaneously.
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