期刊
JOURNAL OF CANCER
卷 7, 期 11, 页码 1481-1486出版社
IVYSPRING INT PUBL
DOI: 10.7150/jca.15466
关键词
stage IA2-IB1 cervical cancer; parametrial metastases; low-risk factors; narrowing resection of parametrial tissues
类别
资金
- National Natural Science Foundation of China [31371452]
- Foundation from Science and Technology Commission of Shanghai Municipality [15JC1403202]
BACKGROUND: Radical hysterectomy with pelvic lymphadenectomy is the standard surgical treatment for patients with stage IA2-IB1 cervical cancer, but the wide excision increases the complications. OBJECTIVE: To analyze the feasibility of narrowing resection of parametrial tissues in stage IA2-IB1 cervical cancer. STUDY DESIGN: Retrospectively analyzed the pathological and clinical data of patients with stage IA2-IB1 cervical cancer who received radical hysterectomy with pelvic lymphadenectomy in OB/GYN Hospital, Fudan University, China from Jan 2008 to Dec 2011. The affected factors of parametrial metastases and outcomes were discussed. The single factor analysis was made with chi 2 test, and the relationship of the resection width of parametrial tissues and the patients' outcomes was analyzed with chi 2 test and log-rank. P-values <0.05 were considered statistically significant. RESULTS: There were 31 cases recurred, 26 cases died of cervical cancer in 513 patients during the follow-up period (from 2 months to 66 months, averaged 39 months). The low-risk factors included diameter of tumor <= 2cm, depth of cervical myometrial invasion < 1/2 and without lymph vascular involvement. There were no parametrial metastases in cases with all three low-risk factors. Whether the resection width of parametrial tissues >= 3cm or not had no statistically significant effect on progression free survival (PFS) or overall survival (OS) of low-risk patients. D2-40 and CD31 were related with parametrial metastases, but not with recurrence or outcomes. CONCLUSIONS: The resection width of parametrial tissues has no effect on PFS and OS of low-risk patients, and narrowing resection of parametrial tissues (<3cm) is feasible.
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