期刊
JOURNAL OF CANCER
卷 7, 期 1, 页码 32-36出版社
IVYSPRING INT PUBL
DOI: 10.7150/jca.13292
关键词
Ribosomal proteins RPL5 and RPS24; Diamond-Blackfan anemia; Soft tissue sarcoma; Rpl5 and Rps24 heterozygous mice
类别
资金
- Mauch Family, a Manton Center for Orphan Disease Research Junior Investigator Award
- NIH [R01 HL107558, K02 HL111156]
- MSMT Navrat grant [LK21307]
Diamond-Blackfan anemia (DBA) is an inherited bone marrow failure syndrome associated with ribosomal protein (RP) gene mutations. Recent studies have also demonstrated an increased risk of cancer predisposition among DBA patients. In this study, we report the formation of soft tissue sarcoma in the Rpl5 and Rps24 heterozygous mice. Our observation suggests that even though one wild-type allele of the Rpl5 or Rps24 gene prevents anemia in these mice, it still predisposes them to cancer development.
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