期刊
JOURNAL OF CANCER
卷 7, 期 10, 页码 1317-1327出版社
IVYSPRING INT PUBL
DOI: 10.7150/jca.15157
关键词
multi-target siRNA; hepatocellular carcinoma (HCC); NET-1; EMS1; VEGF
类别
资金
- foundation of the production-study-research prospective joint research programs of Jiangsu Province, China [BY 2013042-06]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Science Foundation of Nantong City, Jiangsu Province, China [BK 2014001, HS 2014004]
Multiple targets RNAi strategy is a preferred way to treat multigenic diseases, especially cancers. In the study, multi-target siRNAs were designed to inhibit NET-1, EMS1 and VEGF genes in hepatocellular carcinoma (HCC) cells. And multi-target siRNAs showed better silencing effects on NET-1, EMS1 and VEGF, compared with single target siRNA. Moreover, multi-target siRNA showed greater suppression effects on proliferation, migration, invasion, angiogenesis and induced apoptosis in HCC cells. The results suggested that multi-target siRNA might be a preferred strategy for cancer therapy and NET-1, EMS1 and VEGF could be effective targets for HCC treatments.
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