期刊
JOURNAL OF CANCER
卷 7, 期 10, 页码 1242-1249出版社
IVYSPRING INT PUBL
DOI: 10.7150/jca.15062
关键词
pancreatic head cancer; uncinate process; survival; prognosis; recurrence
类别
资金
- Beijing Municipal Science & Technology Commission [Z131107002213043, Z161100000516038]
The special anatomical position accounts for unusual clinicopathological features of uncinate process cancer. This study aimed to compare clinicopathological features of patients with uncinate process cancer to patients with non-uncinate process pancreatic head cancer. Total 160 patients with pancreatic head cancer were enrolled and classified into two groups: uncinate process cancer and non-uncinate process pancreatic head cancer. We found that the ratio of vascular invasion was significantly higher in patients with uncinate process cancer than in patients with non-uncinate process pancreatic head cancer. In addition, the rate of R1 resection was significantly higher in patients with uncinate process cancer. Furthermore, the median disease-free survival (11 months vs. 15 months, p= 0.043) and overall survival (15 months vs. 19 months, p= 0.036) after R0 resection were lower for uncinate process cancer. Locoregional recurrence was more frequent (p= 0.017) and earlier (12 months vs. 36 months; p= 0.002) in patients with uncinate process cancer than in patients with non-uncinate process pancreatic head cancer. In conclusion, uncinate process cancer is more likely to invade blood vessel and has worse prognosis due to the earlier and more frequent locoregional recurrence.
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