4.7 Article

A neutral heteropolysaccharide from Halenia elliptica D. Don: Extraction, structural characterization, antioxidant and antiaging activities

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CARBOHYDRATE POLYMERS
卷 322, 期 -, 页码 -

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ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2023.121330

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Structure-bioactivity; Antioxidant enzyme system; Antiaging activity; Body aging; Halenia elliptica D. Don neutral polysaccharides

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The polysaccharide HEPN-1 from Halenia elliptica D. Don shows strong antioxidant activity, improves learning and memory deficits in cells and mice, and may have the potential to prevent aging.
Halenia elliptica D. Don (H. elliptica), which is also known as heijicao and luanehuamao in China, is recognised as a valuable Tibetan medicinal plant with polysaccharides as the main active ingredient. However, studies on the polysaccharides isolated from H. elliptica are few. A polysaccharide (HEPN-1) with a molecular weight of 10.80 kDa was mainly composed of Gal, Ara, Man, Glc, Rha and Fuc in a molar ratio of 25.56:24.52:4.58:3.37:2.62:1.00. Structural analysis showed that HEPN-1 had a backbone mainly consisting of 413-Galp, 3,6-13-Galp and 3,4,6-13-Galp and branched chains that contained two arabinan (R1 and R2) and two heteropolysaccharide (R3 and R4) side chains. The branching degree of HEPN-1 was 0.52. Within the range of doses (75-300 & mu;g/mL), HEPN-1 increased the enzyme activity of SOD, CAT and GSH-Px and decreased the MDA level in H2O2-induced RAW 264.7 cells in a dose-dependent manner. After 6 weeks of intragastric administration, 300 mg/kg HEPN-1 considerably improved the learning and memory deficits in mice and the antioxidant enzyme system. Moreover, the MDA formation in D-gal-induced aging mice was inhibited, possibly partly via the activation of the PI3K/Akt and Nrf2/HO-1 signalling pathways. Therefore, HEPN-1 could serve as a potential natural antioxidant to prevent aging.

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