期刊
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
卷 304, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2023.123306
关键词
Multifunctional nanoplatform; Gap-enhanced Raman tags; Graphene; Photothermal conversion; Raman mapping imaging
类别
This study presents a novel graphene-wrapped petal-like gap-enhanced Raman tags with mesoporous silica shells (MS-GPGERTs). These nanoplatforms exhibit great potential for early diagnosis and efficient treatment of diseases, especially tumors, due to their multifunctional capabilities of imaging, diagnosis, and therapy. The results show that MS-GP-GERTs have enhanced photothermal effect and excellent stability in physiological environments, making them promising candidates for repeated photothermal therapy. Additionally, MS-GP-GERTs demonstrate low detection limit, large imaging depth, and great imaging ability for simulated biological tissue and cells.
Multifunctional nanoplatform that combine imaging, diagnostic, and therapeutic functions into a single agent have great significance for the early diagnosis and efficient treatment of diseases, particularly tumors. In this study, we report on a novel graphene-wrapped petal-like gap-enhanced Raman tags with mesoporous silica shells (MS-GPGERTs). These MS-GP-GERTs have 4-NBT Raman reporters embedded in the gap between the gold nanocore and the petal-shaped shell and are wrapped in graphene and mesoporous silica. The results of photothermal measurement experiments show that graphene layers significantly enhanced the photothermal effect of gap-enhanced Raman tags (GERTs). The photothermal conversion efficiency of MS-GP-GERTs reaches 40.8%, comparable to pure graphene. Moreover, MS-GP-GERTs show good photothermal performance in agarose phantoms, heating the phantom to 47 degrees C within 5 min under a low power density laser (0.5 W/cm2). MS-GP-GERTs also exhibit excellent photothermal stability and physiological environment stability, making them a promising candidate for repeated photothermal therapy. Raman spectra and mapping imaging experiments demonstrate MS-GP-GERTs' low detection limit (100 fM), large imaging depth (2.74 mm), and excellent ability to image simulated biological tissue and cells. This novel Raman tag has the potential to become a multifunctional nano platform for integrating Raman imaging diagnosis and photothermal therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据