4.2 Review

Recent Progress in Environmentally-Friendly Methods for Chalcone Synthesis

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Review Chemistry, Medicinal

Bis-chalcones: A review of synthetic methodologies and anti-inflammatory effects

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Summary: This review article provides an overview of the chemical structure, chemical properties, and synthesis methods of bis-chalcones. It also emphasizes the anti-inflammatory activity of bis-chalcones and their mechanisms of action.

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Novel Oxygen Fused Bicyclic Derivatives and Antioxidant Labelling: Bioactive Chalcone Based Green Synthesis

Keyur D. Bhatt et al.

Summary: Chalcone has attracted attention due to its diverse biological activities, and green approaches have been found to be more convenient, efficient, and environmentally friendly for synthesizing target compounds.

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Taking the Green Road Towards Pharmaceutical Manufacturing

Hans-Jurgen Federsel

Summary: This short review discusses the importance of the Green Chemistry Principles in designing chemical processes, particularly in the pharmaceutical industry. It also explores the use of life-cycle assessment and metrics to measure the performance of chemical manufacturing.

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Grindstone chemistry: A green approach for the synthesis and derivatization of heterocycles

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Summary: This article introduces mortar-pestle chemistry as a solvent-less alternative technique, which ranges from simple two-component reactions to multicomponent reactions and even material synthesis. It has benevolent characteristics such as cleanliness, safety, and efficiency, and has gradually become a viable alternative to traditional solution-phase reactions.

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Synthesis of Chalcones and Pyrazolines Using NB-Fe3O4@SiO2@CPTMO@DEA-SO3H as an Efficient and Reusable Nanocatalyst

P. Ghorbani et al.

Summary: A rapid and efficient synthesis method for 1,3,5-triaryl-2-pyrazolines has been proposed using a one-pot approach. The reaction is facilitated by the presence of the NB-Fe3O4@SiO2@CPTMO@DEA-SO3H nanocatalyst under solvent-free conditions. The reaction time is short and the yields are high.

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Synthesis of azachalcones, their α-amylase, α-glucosidase inhibitory activities, kinetics, and molecular docking studies

Faiza Saleem et al.

Summary: Diabetes, as a chronic metabolic disorder, has attracted the attention of medicinal chemists and biologists. In this study, twenty-seven azachalcone derivatives were synthesized and evaluated for their antihyperglycemic activities. Five compounds showed good inhibitory activities against alpha-amylase and alpha-glucosidase enzymes, with competitive mode of inhibition.

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A comprehensive review on the antiviral activities of chalcones

Dana Elkhalifa et al.

Summary: This review provides a summary of the antiviral activities of chalcones and their derivatives on a set of human viral infections and their potential for targeting the most recent COVID-19 disease. Studies have shown that chalcones have various pharmacological activities, including antiviral, anti-inflammatory, antimicrobial, and anticancer effects.

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Chalcone Derivatives: Role in Anticancer Therapy

Yang Ouyang et al.

Summary: Chalcones, as precursors for flavonoids and isoflavonoids, have shown broad biological activities and potential as novel anticancer agents. They demonstrate multiple mechanisms against cancers and are expected to improve therapeutic efficacy in combination with other therapies. The full description of toxicity is necessary for their safe clinical use for cancer treatment.

BIOMOLECULES (2021)

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Regioselective synthesis of functionalized pyrazole-chalcones via a base mediated reaction of diazo compounds with pyrylium salts

Lalita Devi et al.

Summary: The reaction involves a base-mediated reaction of triaryl/alkyl pyrylium tetrafluoroborate salts with alpha-diazo-phosphonates, sulfones, and trifluoromethyl compounds to produce functionalized pyrazole-chalcones as tautomeric mixtures. This reaction proceeds through nucleophilic addition of diazo substrates to pyrylium salts, followed by base-mediated pyrylium ring-opening and intramolecular 1,5-cyclization to form formal 1,3-dipolar cycloaddition products. The final products are indenyl-pyrazoles obtained in high yields after undergoing Nazarov-type cyclization upon hydride reduction followed by acidic-workup.

ORGANIC & BIOMOLECULAR CHEMISTRY (2021)

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Synthesis of New Piperazine Substituted Chalcone Sulphonamides as Antibacterial Agents

Yan-Ling Tang et al.

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New chalcone-type compounds and 2-pyrazoline derivatives: synthesis and caspase-dependent anticancer activity

Mohamed Chouiter et al.

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Antiviral properties of chalcones and their synthetic derivatives: a mini review

Radoslav Marinov et al.

PHARMACIA (2020)

Article Chemistry, Multidisciplinary

Concentrated solar radiation as a renewable heat source for a preparative-scale and solvent-free Biginelli reaction

Yatin U. Gadkari et al.

NEW JOURNAL OF CHEMISTRY (2020)

Review Chemistry, Multidisciplinary

Green Chemistry: Principles, Applications, and Disadvantages

Wanisa Abdussalam-Mohammed et al.

CHEMICAL METHODOLOGIES (2020)

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Chalcone derivatives and their antibacterial activities: Current development

Man Xu et al.

BIOORGANIC CHEMISTRY (2019)

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Synthesis and bio-evaluation of indole-chalcone based benzopyrans as promising antiligase and antiproliferative agents

Sampa Gupta et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

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Anticancer activity of ruthenocenyl chalcones and their molecular docking studies

Sharanabasappa Khanapure et al.

JOURNAL OF MOLECULAR STRUCTURE (2018)

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Sustainable chemistry: how to produce better and more from less?

P. Marion et al.

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Green synthesis, characterization and biological evaluation of novel chalcones as anti bacterial agents

Salman A. Khan et al.

ARABIAN JOURNAL OF CHEMISTRY (2017)

Review Chemistry, Multidisciplinary

Chalcone: A Privileged Structure in Medicinal Chemistry

Chunlin Zhuang et al.

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Chalcones as Promising Lead Compounds on Cancer Therapy

Antonio J. Leon-Gonzalez et al.

CURRENT MEDICINAL CHEMISTRY (2015)

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Green solvents for green technologies

Marina Cvjetko Bubalo et al.

JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY (2015)

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Green Synthesis of Chalcones and Microbiological Evaluation

Marina Ritter et al.

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY (2015)

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Novel Pyrazine Analogs of Chalcones: Synthesis and Evaluation of Their Antifungal and Antimycobacterial Activity

Marta Kucerova-Chlupacova et al.

MOLECULES (2015)

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Bio-derived ZnO nanoflower: a highly efficient catalyst for the synthesis of chalcone derivatives

Chandan Tamuly et al.

RSC ADVANCES (2015)

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Advances in Chalcones with Anticancer Activities

Chandrabose Karthikeyan et al.

Recent Patents on Anti-Cancer Drug Discovery (2014)

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Role of microwaves in heterogeneous catalytic systems

Satoshi Horikoshi et al.

CATALYSIS SCIENCE & TECHNOLOGY (2014)

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Synthesis and antibacterial and antifungal evaluation of some chalcone based sulfones and bisulfones

Naveen Kumar Konduru et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2013)

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Microwave-assisted synthesis of nitrogen-containing heterocycles

Arpi Majumder et al.

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Mechanochemistry assisted asymmetric organocatalysis: A sustainable approach

Pankaj Chauhan et al.

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY (2012)

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N. K. Sahu et al.

CURRENT MEDICINAL CHEMISTRY (2012)

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Synthesis and Biological Evaluation of Chalcone Derivatives (Mini Review)

Syed Nasir Abbas Bukhari et al.

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Evolution of microwave irradiation and its application in green chemistry and biosciences

Fatma A. Bassyouni et al.

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Structure and theoretical approaches to a chalcone derivative

Guilherme R. de Oliveira et al.

STRUCTURAL CHEMISTRY (2012)

Article Chemistry, Organic

Green synthesis of novel chalcone and coumarin derivatives via Suzuki coupling reaction

Lucas C. C. Vieira et al.

TETRAHEDRON LETTERS (2012)

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Green Chemistry: Principles and Practice

Paul Anastas et al.

CHEMICAL SOCIETY REVIEWS (2010)

Article Chemistry, Organic

Synthesis of chalcones and flavanones using Julia-Kocienski olefination

Atul Kumar et al.

TETRAHEDRON (2010)

Article Chemistry, Organic

Atom-Efficient, Solvent-Free, Green Synthesis of Chalcones by Grinding

Nora M. Rateb et al.

SYNTHETIC COMMUNICATIONS (2009)

Article Biochemistry & Molecular Biology

Natural and non-natural prenylated chalcones: Synthesis, cytotoxicity and anti-oxidative activity

Susanne Vogel et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2008)

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Synthesis of chalcones catalyzed by a novel solid sulfonic acid from bamboo

Qiong Xu et al.

CATALYSIS COMMUNICATIONS (2008)

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Bronsted acidic ionic liquids as dual catalyst and solvent for environmentally friendly synthesis of chalcone

Jianghan Shen et al.

JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL (2008)

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An efficient green procedure for the synthesis of chalcones using C-200 as solid support under grinding conditions

S. Kumar et al.

Green Chemistry Letters and Reviews (2008)

Review Chemistry, Medicinal

A review of anti-infective and anti-inflammatory chalcones

Zdzislawa Nowakowska

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2007)

Article Chemistry, Medicinal

QSAR studies on chalcones and flavonoids as anti-tuberculosis agents using genetic function approximation (GFA) method

Ponnurengarn Malliappan Sivakumar et al.

CHEMICAL & PHARMACEUTICAL BULLETIN (2007)

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Ultrasound accelerated Claisen-Schmidt condensation:: A green route to chalcones

V. Calvino et al.

APPLIED SURFACE SCIENCE (2006)

Article Chemistry, Physical

Solvent free synthesis of chalcone and flavanone over zinc oxide supported metal oxide catalysts

S Saravanamurugan et al.

CATALYSIS COMMUNICATIONS (2005)

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Antifungal activity and studies on mode of action of novel xanthoxyline-derived chalcones

P Boeck et al.

ARCHIV DER PHARMAZIE (2005)

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Organic base-mediated condensation of pyridinecarboxaldehydes to azachalcones

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ADVANCED SYNTHESIS & CATALYSIS (2005)

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Chalcones: An update on cytotoxic and chemoprotective properties

ML Go et al.

CURRENT MEDICINAL CHEMISTRY (2005)

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3D QSAR studies on antimalarial alkoxylated and hydroxylated chalcones by CoMFA and CoMSIA

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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2004)

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TETRAHEDRON LETTERS (2003)

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Design, synthesis, and evaluation of novel boronic-chalcone derivatives as antitumor agents

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