相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。FAK in Cancer: From Mechanisms to Therapeutic Strategies
Hsiang-Hao Chuang et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
Triple negative breast cancer: Pitfalls and progress
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NPJ BREAST CANCER (2022)
Targeting FAK in anticancer combination therapies
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NATURE REVIEWS CANCER (2021)
Phase 2 study of the focal adhesion kinase inhibitor defactinib (VS-6063) in previously treated advanced KRAS mutant non-small cell lung cancer
David E. Gerber et al.
LUNG CANCER (2020)
Structural basis of Focal Adhesion Kinase activation on lipid membranes
Ivan Acebron et al.
EMBO JOURNAL (2020)
Efficacy of the highly selective focal adhesion kinase inhibitor BI 853520 in adenocarcinoma xenograft models is linked to a mesenchymal tumor phenotype
Ulrich A. Hirt et al.
ONCOGENESIS (2018)
The FAK inhibitor BI 853520 exerts anti-tumor effects in breast cancer
Stefanie Tiede et al.
ONCOGENESIS (2018)
Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease
Giampaolo Bianchini et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2016)
Oncogenic activation of FAK drives apoptosis suppression in a 3D-culture model of breast cancer initiation
Scott Walker et al.
ONCOTARGET (2016)
A phase I study of VS-6063, a second-generation focal adhesion kinase inhibitor, in patients with advanced solid tumors
Suzanne F. Jones et al.
INVESTIGATIONAL NEW DRUGS (2015)
FAK signaling in human cancer as a target for therapeutics
Brian Y. Lee et al.
PHARMACOLOGY & THERAPEUTICS (2015)
High focal adhesion kinase expression in breast carcinoma is associated with lymphovascular invasion and triple-negative phenotype
Vita M. Golubovskaya et al.
BMC CANCER (2014)
A small molecule FAK kinase inhibitor, GSK2256098, inhibits growth and survival of pancreatic ductal adenocarcinoma cells
Jianliang Zhang et al.
CELL CYCLE (2014)
Merlin Deficiency Predicts FAK Inhibitor Sensitivity: A Synthetic Lethal Relationship
Irina M. Shapiro et al.
SCIENCE TRANSLATIONAL MEDICINE (2014)
FAK in cancer: mechanistic findings and clinical applications
Florian J. Sulzmaier et al.
NATURE REVIEWS CANCER (2014)
Clinical and biologic features of triple-negative breast cancers in a large cohort of patients with long-term follow-up
L. Malorni et al.
BREAST CANCER RESEARCH AND TREATMENT (2012)
Safety, Pharmacokinetic, and Pharmacodynamic Phase I Dose-Escalation Trial of PF-00562271, an Inhibitor of Focal Adhesion Kinase, in Advanced Solid Tumors
Jeffrey R. Infante et al.
JOURNAL OF CLINICAL ONCOLOGY (2012)
Integrated genomic analyses of ovarian carcinoma (vol 474, pg 609, 2011)
J. G. Vockley et al.
NATURE (2012)
Comprehensive molecular portraits of human breast tumours
Daniel C. Koboldt et al.
NATURE (2012)
PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments
Isabelle Tanjoni et al.
CANCER BIOLOGY & THERAPY (2010)
Tyrosine Phosphorylation Profiling Reveals the Signaling Network Characteristics of Basal Breast Cancer Cells
Falko Hochgraefe et al.
CANCER RESEARCH (2010)
Pyk2 Inhibition of p53 as an Adaptive and Intrinsic Mechanism Facilitating Cell Proliferation and Survival
Ssang-Taek Lim et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
The FERM domain: organizing the structure and function of FAK
Margaret C. Frame et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
Signal transduction by focal adhesion kinase in cancer
Jihe Zhao et al.
CANCER AND METASTASIS REVIEWS (2009)
Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility
Alok Tomar et al.
CURRENT OPINION IN CELL BIOLOGY (2009)
Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK
Sara M. Weis et al.
JOURNAL OF CELL BIOLOGY (2008)
PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility
Yang Lim et al.
JOURNAL OF CELL BIOLOGY (2008)
Integrin-regulated FAK-Src signaling in normal and cancer cells
Satyajit K. Mitra et al.
CURRENT OPINION IN CELL BIOLOGY (2006)
Intrinsic focal adhesion kinase activity controls orthotopic breast carcinoma metastasis via the regulation of urokinase plasminogen activator expression in a syngeneic tumor model
S. K. Mitra et al.
ONCOGENE (2006)
Focal adhesion kinase: In command and control of cell motility
SK Mitra et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)